1257393-74-0

Basic information

• Product Name: (4-methylthiophenyl)acetic acid hydrazide
• Synonyms: (4-methylthiophenyl)acetic acid hydrazide
• CAS NO: 1257393-74-0
• Molecular Weight: 196.273
• Mol File: 1257393-74-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4-methylthiophenyl)acetic acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methylthiophenyl)acetic acid hydrazide(1257393-74-0)
• EPA Substance Registry System: (4-methylthiophenyl)acetic acid hydrazide(1257393-74-0)

Safety Data

• Hazardous Substances Data: 1257393-74-0(Hazardous Substances Data)

Upstream product

• 14062-27-2 ethyl 4-methylthiophenylacetate 
• 16188-55-9 2-(4-(methylthio)phenyl)acetic acid 

Downstream Products

• 1257393-75-1 5-(4-methylthiobenzyl)-1,3,4-oxadiazole-2-thione 
• 1287721-72-5 2-(4-methylthiobenzyl)-6-(4-chloro-phenyl-2-furylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one 
• 1287721-73-6 2-(4-methylthiobenzyl)-6-(4-nitro-phenyl-2-furylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one 
• 1287721-74-7 C₂₃H₁₆N₄O₄S₂ 
• 1287721-75-8 2-(4-methylthiobenzyl)-6-(4-bromo-phenyl-2-furylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one 
• 1287721-76-9 C₂₃H₁₄Cl₃N₃O₂S₂ 
• 1287721-77-0 C₂₃H₁₅ClFN₃O₂S₂ 
• 1287721-79-2 C₂₄H₁₈N₄O₄S₂ 
• 1287721-80-5 C₂₃H₁₅ClN₄O₄S₂ 
• 1287721-81-6 C₂₃H₁₅Cl₂N₃O₂S₂ 
• 1287721-82-7 2-(4-methylthiobenzyl)-6-(3,4-dimethoxy-benzylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one 
• 1287721-83-8 C₂₁H₁₈N₄O₅S₂ 
• 1287721-84-9 C₁₉H₁₅N₃O₂S₂ 
• 1287721-85-0 2-(4-methylthiobenzyl)-6-(3,5-difluoro-benzylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one 

Relevant articles and documents

Three-component reaction: Synthesis, characterization, and biological study of some fused bridgehead nitrogen heterocyclic systems containing 4-methylthiophenyl moiety

Several substituted thiazolo-[3,2-b]-1,2,4-triazole derivatives 4 were synthesized by a one-pot, three-component reaction of 3-(4-methylthiobenzyl)-1, 2,4-triazole-5-thiol 3, substituted 5-aryl-furan-2-carboxaldehydes/substituted aromatic aldehydes, and monochloroacetic acid in acetic acid using acetic anhydride and anhydrous sodium acetate. Compound 3 was obtained from 4-methylthiophenyl acetic acid by esterification followed by hydrazinolysis. All structures of the newly synthesized compounds were elucidated by elemental analysis and spectral data. The newly synthesized compounds were also screened for their antimicrobial and anti-inflammatory activities. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives

The acid hydrazides (2) derived from ibuprofen and 4-methylthiophenyl acetic acids have been subjected to cyclization with carbon disulphide under basic conditions to yield 1,3,4-oxadiazol-2-thiones (3) which on aminomethylation with formaldehyde and secondary amines afforded a series of Mannich bases (4 and 5). Purity of the compounds has been confirmed by TLC. Structures of these compounds were established on the basis of elemental analyses and spectral studies. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and antimicrobial activities.