1259518-19-8

Basic information

• Product Name: 5-(3-bromo-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile
• Synonyms: 5-(3-bromo-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile
• CAS NO: 1259518-19-8
• Molecular Weight: 324.201
• Mol File: 1259518-19-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5-(3-bromo-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-bromo-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile(1259518-19-8)
• EPA Substance Registry System: 5-(3-bromo-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile(1259518-19-8)

Safety Data

• Hazardous Substances Data: 1259518-19-8(Hazardous Substances Data)

Upstream product

• 515832-52-7 5-bromo-2-[(1-methylethyl)oxy]benzonitrile 
• 40530-18-5 5-bromo-2-hydroxybenzonitrile 
• 37159-60-7 3-bromo-5-chloro-[1,2,4]thiadiazole 
• 1258440-84-4 2-[(1-methylethyl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 

Downstream Products

• 1344998-54-4 C₂₉H₃₄N₄O₃S 
• 1344997-61-0 5-{3-[2-ethyl-3-(2-oxoethyl)phenyl]-1,2,4-thiadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile 
• 1344997-60-9 5-(3-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazol-5-yl)-2-[(1-methylethyl)oxy]benzonitrile 
• 1413605-81-8 (S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride 
• 1413605-93-2 (S)-methyl 2-(N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)sulfamoyl)acetate 
• 1413605-87-4 (S)-5-(3-(1-(bis(2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride 
• 1413605-69-2 (S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)sulfamide 
• 1413605-57-8 (S)-5-(3-(1-amino-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride 
• 1413605-99-8 (S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-2-hydroxyethanesulfonamide 
• 1260023-63-9 5-[3-(2-ethyl-3-formylphenyl)-1,2,4-thiadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile 
• 1260023-61-7 ethyl 4-[3-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]butanoate 

Relevant articles and documents

SPIRO COMPOUND AND USE THEREOF

The present disclosure relates to a series of tricyclic compounds and the use thereof as receptor agonists of sphingosine-1-phosphate subtype 1 (S1P1), and in particular relates to compounds as shown in formula (I) or pharmaceutically acceptable salts the

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The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

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5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.