1259528-76-1Relevant articles and documents
Molecular nanofibers of olsalazine form supramolecular hydrogels for reductive release of an anti-inflammatory agent
Li, Xinming,Li, Jiayang,Gao, Yuan,Kuang, Yi,Shi, Junfeng,Xu, Bing
, p. 17707 - 17709 (2010)
Conjugation of tripeptide derivatives with olsalazine, a clinically used anti-inflammatory prodrug, yields small molecules that self-assemble in water to form supramolecular hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the controlled release of 5-aminosalicylic acid as the anti-inflammatory agent. This methodology will ultimately lead to new biomaterials for site-specific drug delivery.
