126275-19-2

Basic information

• Product Name: (R)-(+)-N-ALLYL-ALPHA-METHYLBENZYLAMINE&
• Synonyms: (r)-(+)-n-allyl-α-methylbenzylamine;Allyl-(1-phenyl-ethyl)-amine;(R)-N-(1-phenylethyl)prop-2-en-1-amine;EOS-61792
• CAS NO: 126275-19-2
• Molecular Formula: C₁₁H₁₅N
• Molecular Weight: 161.24
• Product Categories: Amines;Chiral Building Blocks;Organic Building Blocks
• Mol File: 126275-19-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 58-59 °C1 mm Hg(lit.)
• Flash Point: 187 °F
• Appearance: /
• Density: 0.919 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0855mmHg at 25°C
• Refractive Index: n20/D 1.5145(lit.)
• CAS DataBase Reference: (R)-(+)-N-ALLYL-ALPHA-METHYLBENZYLAMINE&(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-N-ALLYL-ALPHA-METHYLBENZYLAMINE&(126275-19-2)
• EPA Substance Registry System: (R)-(+)-N-ALLYL-ALPHA-METHYLBENZYLAMINE&(126275-19-2)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 23-26-36/37/39-45
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 126275-19-2(Hazardous Substances Data)

Usage

Description

(R)-(+)-N-ALLYL-ALPHA-METHYLBENZYLAMINE& is an organic compound with the molecular formula C11H15N, belonging to the class of amines. It features an allyl group in its structure, which contributes to its unique properties and applications. (R)-(+)-N-ALLYL-ALPHA-METHYLBENZYLAMINE& is known for its stereochemistry and reactivity, making it a valuable asset in the field of organic chemistry and drug discovery.

Uses

Used in Pharmaceutical Synthesis:
(R)-(+)-N-ALLYL-ALPHA-METHYLBENZYLAMINE& is used as a key component in the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
(R)-(+)-N-ALLYL-ALPHA-METHYLBENZYLAMINE& also finds application in the production of agrochemicals, where it can be utilized to create new products for agricultural use, such as pesticides or fertilizers.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
(R)-(+)-N-ALLYL-ALPHA-METHYLBENZYLAMINE& is employed as a chiral auxiliary in asymmetric synthesis, a crucial technique in the production of enantiomerically pure compounds. This application is particularly important in the pharmaceutical industry, where the desired biological activity is often associated with a specific enantiomer.
Used in the Production of Fine Chemicals:
(R)-(+)-N-ALLYL-ALPHA-METHYLBENZYLAMINE& is also used in the production of fine chemicals, which are high-purity chemicals used in various industries, including pharmaceuticals, fragrances, and flavors.
Used as a Building Block in Organic Synthesis:
(R)-(+)-N-ALLYL-ALPHA-METHYLBENZYLAMINE& serves as a building block in organic synthesis, allowing chemists to construct more complex molecules with specific properties and functions. This versatility makes it a valuable tool in the development of new materials and compounds for various applications.

InChI:InChI=1/C11H15N/c1-3-9-12-10(2)11-7-5-4-6-8-11/h3-8,10,12H,1,9H2,2H3/t10-/m0/s1

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 106-95-6 allyl bromide 
• 924276-59-5 methyl {N-allyl-N-[(1R)-1-phenylethyl]amino}propanoate 
• 35021-93-3 N-(1-phenylethylidene)prop-2-en-1-amine 
• 4873-09-0 allyl tosylate 
• 98-86-2 acetophenone 
• 107-11-9 1-amino-2-propene 

Downstream Products

• 186299-48-9 (R)-N-allyl-N-(1-phenylethyl)methoxycarbonylacetamide 
• 624738-97-2 (3R,5E,αR)-methyl 3-(N-allyl-N-α-methylbenzylamino)hept-5-enoate 
• 900518-23-2 tert-butyl (2R,3R,6S,αR)-3-phenyl-4-(α-methylbenzyl)-6-methylthiomorpholine-2-carboxylate 
• 924276-78-8 methyl 2-{N-allyl-N-[(1R)-1-phenylethyl]aminomethyl}acrylate 
• 924276-59-5 methyl {N-allyl-N-[(1R)-1-phenylethyl]amino}propanoate 
• 924276-60-8 methyl 3-{N-allyl-N-[(1R)-1-phenylethyl]amino}-2-methylpropionate 
• 924276-66-4 methyl (3S,4S)-3,4-dimethyl-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate 
• 924276-63-1 methyl 2-{N-allyl-N-[(1R)-1-phenylethyl]aminomethyl}pent-4-enoate 

Relevant articles and documents

(E)-Alkenes as replacements of amide bonds: Development of novel and potent acyclic CGRP receptor antagonists

A new class of CGRP receptor antagonists was identified by replacing the central amide of a previously identified anilide lead structure with ethylene, ethane, or ethyne linkers. (E)-Alkenes as well as alkynes were found to preserve the proper bioactive conformation of the amides, necessary for efficient receptor binding. Further exploration resulted in several potent compounds against CGRP-R with low susceptibility to P-gp mediated efflux.

Kolbe Anodic Decarboxylation as a Green Way to Access 2-Pyrrolidinones

Nootropic compounds are a group of pharmacologically active pyrrolidones. These molecules, which enhance cognition properties and possess a large prescription field, are particularly interesting synthetic targets for the pharmaceutical industry. In this Article, we disclose an effective and environmentally friendly pyrrolidinone synthesis using electrosynthesis. The newly developed methodology includes a Kolbe decarboxylation, followed by an intramolecular radical cyclization and a radical-radical cross-coupling.

N,2,3,4-Tetrasubstituted Pyrrolidines through Tandem Lithium Amide Conjugate Addition/Radical Cyclization/Oxygenation Reactions

Enantioselective syntheses of densely functionalized pyrrolidines deriving their chirality from (R)-1-(phenyl)ethylamine are reported. Allylic amines and β-substituted-α,β-unsaturated esters are used as the building blocks in this one-pot reaction. Single