126296-63-7Relevant articles and documents
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against β-lactamase
Babaoglu, Kerim,Simconov, Anton,Irwin, John J.,Nelson, Michael E.,Feng, Brian,Thomas, Craig J.,Cancian, Laura,Costi, M. Paola,Maltby, David A.,Jadhav, Ajit,Inglese, James,Austin, Christopher P.,Shoichet, Brian K.
, p. 2502 - 2511 (2008)
High-throughput screening (HTS) is widely used in drug discovery. Especially for screens of unbiased libraries, false positives can dominate "hit lists": their origins are much debated. Here we determine the mechanism of every active hit from a screen of