1263375-23-0

Basic information

• Product Name: 2,5-Difluoropyridine-4-boronic acid
• Synonyms: 2,5-Difluoropyridine-4-boronic acid
• CAS NO: 1263375-23-0
• Molecular Formula: C₅H₄BF₂NO₂
• Molecular Weight: 158.8985664
• Mol File: 1263375-23-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 305.2±52.0 °C(Predicted)
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 6.31±0.58(Predicted)
• CAS DataBase Reference: 2,5-Difluoropyridine-4-boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Difluoropyridine-4-boronic acid(1263375-23-0)
• EPA Substance Registry System: 2,5-Difluoropyridine-4-boronic acid(1263375-23-0)

Safety Data

• Hazardous Substances Data: 1263375-23-0(Hazardous Substances Data)

Usage

General Description

2,5-Difluoropyridine-4-boronic acid is a chemical compound that contains a pyridine ring with two fluorine atoms and a boronic acid functional group attached to the 4th carbon atom. It is commonly used as a building block in organic synthesis, particularly in the field of medicinal chemistry and pharmaceuticals. The boronic acid group gives the compound the ability to form stable complexes with other molecules, making it a valuable tool for the development of new drugs. Additionally, the fluorine atoms can influence the compound's reactivity and bioavailability, making it an important component in drug discovery research.

Upstream product

• 5419-55-6 Triisopropyl borate 
• 84476-99-3 2,5-difluoropyridine 

Relevant articles and documents

PHENYL-HETEROARYL AMINE COMPOUNDS AND THEIR USES

The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds of Formula I, and pharmaceutical compositions comprising such compounds

N-ACYL PYRIDINE BIARYL COMPOUNDS AND THEIR USES

The present invention provides a compound of general formula:wherein Z2-Z6 include one or two nitrogen atoms as described herein, including pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. These compounds inhibit the activity of CDK9 and are thus useful as pharmaceuticals. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds of Formula I and isomers thereof, and pharmaceutical compositions comprising such compounds.

N-ACYL PYRIMIDINE BIARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

The present invention provides a compound of the general formula (1): wherein one of X and Y is N and the other is an optionally substituted carbon atom, and Z2-Z5 represent one or two nitrogen atoms, as further described herein, including pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. These compounds inhibit the activity of CDK9 and are thus useful as pharmaceuticals and as components of pharmaceutical compositions. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds described herein or pharmaceutical compositions comprising such compounds.