126378-42-5 Usage
Description
4-Methoxy-3-(triisopropylsilyl)pyridine is a pyridine derivative with the molecular formula C15H27NOSi. It is a strong base and a versatile catalyst in organic synthesis, characterized by its highly nucleophilic nature due to the triisopropylsilyl group attached to the pyridine nitrogen atom. The methoxy group enhances the compound's reactivity and stability, making it a valuable asset in the synthesis of pharmaceuticals, agrochemicals, and materials science applications.
Used in Pharmaceutical Industry:
4-Methoxy-3-(triisopropylsilyl)pyridine is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its ability to facilitate challenging transformations in organic chemistry allows for the creation of complex molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Methoxy-3-(triisopropylsilyl)pyridine serves as a key component in the synthesis of agrochemicals. Its reactivity and stability contribute to the development of effective and environmentally friendly products for agricultural use.
Used in Materials Science:
4-Methoxy-3-(triisopropylsilyl)pyridine is utilized in materials science as a catalyst and building block for the synthesis of advanced materials. Its versatile reactivity enables the creation of novel materials with unique properties for various applications, such as electronics, energy storage, and nanotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 126378-42-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,3,7 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 126378-42:
(8*1)+(7*2)+(6*6)+(5*3)+(4*7)+(3*8)+(2*4)+(1*2)=135
135 % 10 = 5
So 126378-42-5 is a valid CAS Registry Number.
126378-42-5Relevant articles and documents
DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
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Page/Page column 23-24, (2010/07/04)
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
Asymmetric synthesis of 2-alkyl(aryl)-2,3-dihydro-4-pyridones by addition of Grignard reagents to chiral 1-acyl-4-methoxypyridinium salts
Comins, Daniel L.,Joseph, Sajan P.,Goehring, R. Richard
, p. 4719 - 4728 (2007/10/02)
The asymmetric synthesis of 2-alkyl(aryl)-2,3-dihydro-4-pyridones 3 by addition of various Grignard reagents to chiral 1-acyl-4-methoxypyridinium salts was studied in detail. Chiral pyridinium salts formed from 4-methoxy-3-(triisopropylsilyl)pyridine (2f), and (-)-8-arylmenthyl chloroformates, or (-)-trans-2-(α-cumyl)cyclohexyl chloroformate, gave the best results, with diastereomeric selectivities ranging from 60 to 94%. When 4-methoxy-3-(trialkylstannyl)pyridines were used, destannylated 2-alkyl-2,3-dihydropyridones 3a resulted in good yield. The size of the C-3 substituent, the auxiliary, the solvent, the reaction temperature, and the structure of the Grignard reagent were varied to determine their effect on the yield and the degree of asymmetric induction. The chiral auxiliary and the C-3 triisopropylsilyl group can be removed from 3f, and the auxiliary recovered, on treatment with sodium methoxide in methanol followed by aqueous acid. The resulting 2,3-dihydropyridones 8 are useful chiral building blocks for the enantioselective synthesis of various alkaloids.
