126399-19-7

Basic information

• Product Name: L-Tyrosyl-D-alanyl-glycyl-L-phenylalanyl-L-neopentylglycyl-L-arginine
• Synonyms: L-Tyrosyl-D-alanyl-glycyl-L-phenylalanyl-L-neopentylglycyl-L-arginine
• CAS NO: 126399-19-7
• Molecular Weight: 739.872
• Mol File: 126399-19-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Tyrosyl-D-alanyl-glycyl-L-phenylalanyl-L-neopentylglycyl-L-arginine(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosyl-D-alanyl-glycyl-L-phenylalanyl-L-neopentylglycyl-L-arginine(126399-19-7)
• EPA Substance Registry System: L-Tyrosyl-D-alanyl-glycyl-L-phenylalanyl-L-neopentylglycyl-L-arginine(126399-19-7)

Safety Data

• Hazardous Substances Data: 126399-19-7(Hazardous Substances Data)

Upstream product

• 126399-16-4 Benzyloxycarbonyl-L-phenylalanyl-D,L-neopentylglycyl-L-arginine 
• 126399-14-2 Tert-butyloxycarbonyl-D,L-neopentylglycyl-L-arginine 
• 126399-12-0 p-Nitrophenyl ester of tert-butyloxycarbonyl-D,L-neopentylglycine 
• 74-79-3 L-arginine 
• 126399-17-5 Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycyl-L-phenylalanyl-D,L-neopentylglycyl-L-arginine 

Downstream Products

• 74-79-3 L-arginine 

Relevant articles and documents

PREPARATION AND CHARACTERIZATION OF NEW ANALOGUES OF DALARGIN

Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycyl-L-phenylalanyl-DL-neopentylglycyl-L-arginine was prepared by means of fragment condensation in solution.Protecting groups were removed with trifluoroacetic and the diastereoisomeric peptides were separated employing high-performance liquid chromatography (HPLC) and the absolute configuration of neopentylglycine in each diastereomer was determined by two different methods: analysis of enzymatic degradation with carboxypeptidaseB and 1H NMR spectroscopic data.The hexapeptide with L-neopentylglycine in position 5 exhibited a 20 times higher activity in a standard test on isolated guinea-pig ileum (GPI).The hexapeptide with D-neopentylglycine in position 5 exhibited a 4 times higher activity than Dalargin in the GPI test but its effect was prolonged in comparison to the analog with L-neopentylglycine and Dalargin.