126504-86-7

Basic information

• Product Name: Pyrimidine, 5-(chloromethyl)-2-methyl- (9CI)
• Synonyms: Pyrimidine, 5-(chloromethyl)-2-methyl- (9CI);5-(chloromethyl)-2-methylpyrimidine;5-(CHLOROMETHYL)-2-METHYLPYRIMIDINE,PURITY:95% MIN(HPLC);Pyrimidine,5-(chloromethyl)-2-methyl-;5-(chloroMethyl)-2-MethylpyriMid
• CAS NO: 126504-86-7
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.58618
• Product Categories: PYRIMIDINE
• Mol File: 126504-86-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 213.8℃
• Flash Point: 103.3℃
• Appearance: /
• Density: 1.189
• Vapor Pressure: 0.234mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: 2-8°C
• PKA: 1.30±0.22(Predicted)
• CAS DataBase Reference: Pyrimidine, 5-(chloromethyl)-2-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 5-(chloromethyl)-2-methyl- (9CI)(126504-86-7)
• EPA Substance Registry System: Pyrimidine, 5-(chloromethyl)-2-methyl- (9CI)(126504-86-7)

Safety Data

• Hazardous Substances Data: 126504-86-7(Hazardous Substances Data)

Usage

General Description

Pyrimidine, 5-(chloromethyl)-2-methyl- (9CI) is a chemical compound with the molecular formula C7H8ClN3. It is a derivative of pyrimidine and is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. The chloromethyl group on the molecule makes it reactive and useful for forming new carbon-carbon bonds in organic synthesis. It is also used as a starting material for the production of other pyrimidine derivatives with potential biological activities. Additionally, this compound has been studied for its potential use in the development of new antineoplastic and antiviral drugs.

InChI:InChI=1/C6H7ClN2/c1-5-8-3-6(2-7)4-9-5/h3-4H,2H2,1H3

Upstream product

• 22868-76-4 2,5-dimethylpyrimidine 
• 5194-32-1 2-methylpyrimidine-5-carboxylic acid 
• 2239-83-0 5-(Hydroxymethyl)-2-methylpyrimidine 

Relevant articles and documents

AZAINDOLES AND METHODS OF USE THEREOF

Disclosed are compounds according to Formula (I) or (II), and pharmaceutical compositions comprising them. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I) or (II). (Formulae (I, (II))

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

(2,5)Pyrimidinophanes: Synthesis and Molecular Structure

The title compounds 1 and 2 are synthesized by photolytic sulfur extrusion from 2,11-dithia(2,5)pyrimidinophane 17.The molecular structures of 1 and 2 are determined by X-ray structure analysis and are discussed with regard to the steric strain in these molecules.Thermolysis of - or -trimethylammonium hydroxide (10 or 11) does not generate 1 and 2. α-Chlorination of 2,5-dimethylpyrimidine (3) with N-chlorosuccinimide provides the required precursors 4 - 6.