126532-04-5Relevant articles and documents
Method for selectively synthesizing halogenated arylamine through copper catalysis (by machine translation)
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Paragraph 0083-0086, (2020/12/30)
The method comprises the following steps: reacting a substrate with a halogenating reagent (III) in an organic solvent to obtain a catalyst. The reaction 0 - 80 °C is reacted at 0.5 - 6h under the action of an oxidizing agent, and after the reaction is finished, the reaction liquid is subjected to post-treatment to obtain the product halogenated aromatic amine compound. To the invention, direct synthesis of the halogenated aromatic amine compounds is achieved for the first time, and the problems that in the traditional method, the metal catalyst is expensive, the halogenated reagent toxicity is large, byproducts are large and the like are solved. At the same time, the product can take off the pyridine guide group through simple hydrolysis, and further functional groups can be combined into an aromatic heterocyclic compound. The method is simple and convenient to operate, mild in reaction conditions, high in selectivity, high in product yield and wide in substrate applicability, and is an efficient organic synthesis means. : Substrate: Halogenating agent: Product: (by machine translation)
Halogen bonding synthon modularity in coordination compounds
Khavasi, Hamid Reza,Norouzi, Fataneh,Azhdari Tehrani, Alireza
, p. 2579 - 2583 (2015/06/16)
In this Communication, the modulation of halogen bonding synthons in the crystal structure of [HgBr2(L3,4-diCl)] from [HgBr2(L3-Cl)] and [HgBr2(L4-Cl)], as single components, where L is a N
Effect of halogen bonding interaction on supramolecular assembly of halogen-substituted phenylpyrazinamides
Khavasi, Hamid Reza,Tehrani, Alireza Azhdari
, p. 3222 - 3235 (2013/06/27)
A series of halogen-substituted phenylpyrazinamides have been synthesized and crystallographically characterized in order to investigate the effect of halogen bonding interaction on supramolecular assembly of N-phenylpyrazine-2- carboxamide derivatives. The notable feature in crystal structures of meta- and para-iodinated, brominated and chlorinated compounds is that there is a tendency to form a halogen bonding synthon between adjacent halophenyl and prazine/halophenyl rings. Influence of these halogen bonding interactions on supramolecular assemblies have been discussed with the help of geometrical analysis and theoretical calculations. The X...N halogen bonding distances are 2.2-7.7% shorter than the sum of the van der Waals radii of the nitrogen and halogen atoms. Also, theoretical methods show the N...X halogen bonding energies within a range of -9.43 to -23.67 kJ mol-1. Our studies show that the selection of halogen atom as well as the position of substitution on phenylpyrazinamide compound may be important for crystal design based on halogen bonding.
