126789-45-5

Basic information

• Product Name: C₇₉H₁₅₅NO₁₃Si₄
• Synonyms: C₇₉H₁₅₅NO₁₃Si₄
• CAS NO: 126789-45-5
• Molecular Weight: 1439.44
• Mol File: 126789-45-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₇₉H₁₅₅NO₁₃Si₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₇₉H₁₅₅NO₁₃Si₄(126789-45-5)
• EPA Substance Registry System: C₇₉H₁₅₅NO₁₃Si₄(126789-45-5)

Safety Data

• Hazardous Substances Data: 126789-45-5(Hazardous Substances Data)

Upstream product

• 130612-74-7 C₇₂H₁₄₆O₉Si₅ 
• 129873-35-4 C₆₈H₁₃₈O₁₀Si₄ 
• 26250-84-0 (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid 
• 67-56-1 methanol 
• 126789-44-4 C₈₀H₁₅₅NO₁₁S₂Si₄ 

Downstream Products

• 118977-92-7 C₇₇H₁₄₉NO₁₂Si₄ 

Relevant articles and documents

Chemistry of tricarbonyl hemiketals and application of Evans' technology to the total synthesis of the immunosuppressant (-)-FK-506

Details of model studies probing the chemistry of the tricarbonyl region of FK-506 are presented, and their use in designing a successful route to this immunosuppressant is outlined. Application of asymmetric oxazolidinone alkylation/aldol methodology to a convergent, highly flexible synthesis of the C10-C18 fragment and to improvements in the preparation of the C20-C34 segment are also discussed.

Efficient Degradation of FK-506 to a Versatile Synthetic Intermediate

An 11-step degradation of natural FK-506 (1) to selectively protected C10-C34 synthetic intermediate 2 has been accomplished in 14percent overall yield.The key steps include; (a) lead tetracetate mediated C9-C10 bond cleavage of 24,32-bis(triisopropylsilyl)-FK-506 (3), (b) simultaneous C10 ester, C22 ketone reduction/C26 oxygen deacylation, and (c) selective bis(triethylsilylation) of the resulting triols 7a,b.The degradate 2 is ready for reacylation at the C26 hydroxyl terminus; hydrolysis of the dimethyl acetal moiety then provides an aldehyde ready for homologation at the C10 terminus.