1268085-01-3

Basic information

• Product Name: 1-{2-[4-(tert-butyl)phenyl]-4-methylthiazol-5-yl}ethanone
• Synonyms: 1-{2-[4-(tert-butyl)phenyl]-4-methylthiazol-5-yl}ethanone
• CAS NO: 1268085-01-3
• Molecular Weight: 273.399
• Mol File: 1268085-01-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-{2-[4-(tert-butyl)phenyl]-4-methylthiazol-5-yl}ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{2-[4-(tert-butyl)phenyl]-4-methylthiazol-5-yl}ethanone(1268085-01-3)
• EPA Substance Registry System: 1-{2-[4-(tert-butyl)phenyl]-4-methylthiazol-5-yl}ethanone(1268085-01-3)

Safety Data

• Hazardous Substances Data: 1268085-01-3(Hazardous Substances Data)

Upstream product

• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 56108-12-4 4-tert-butylbenzamide 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 57774-77-3 4-t-butyl phenyl thioamide 
• 1694-29-7 3-chloropentane-2,4-dione 

Downstream Products

• 1537168-39-0 2-{1-[2-(4-(tert-butyl)phenyl)-4-methylthiazol-5-yl]-ethylidene}hydrazinecarboximidamide 

Relevant articles and documents

Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity

A new series of phenylthiazoles with t-butyl lipophilic component was synthesized and their antibacterial activity against a panel of multidrug-resistant bacterial pathogens was evaluated. Five compounds demonstrated promising antibacterial activity against methicillin-resistant staphylococcal strains and several vancomycin-resistant staphylococcal and enterococcal species. Additionally, three derivatives 19, 23 and 26 exhibited rapid bactericidal activity, and remarkable ability to disrupt mature biofilm produced by MRSA USA300. More importantly, a resistant mutant to 19 couldn't be isolated after subjecting MRSA to sub-lethal doses for 14 days. Lastly, this new series of phenylthiazoles possesses an advantageous attribute over the first-generation compounds in their stability to hepatic metabolism, with a biological half-life of more than 9 h.

ANTIMICROBIAL SUBSTITUTED THIAZOLES AND METHODS OF USE

Disclosed are compositions having activity against MRSA and/or VRSA, and methods of using the compositions to treat microbial infections.