126884-67-1

Basic information

• Product Name: (R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one
• Synonyms: (R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one
• CAS NO: 126884-67-1
• Molecular Weight: 367.442
• Mol File: 126884-67-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one(126884-67-1)
• EPA Substance Registry System: (R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one(126884-67-1)

Safety Data

• Hazardous Substances Data: 126884-67-1(Hazardous Substances Data)

Upstream product

• 115378-74-0 (2R,5R)-N-acetylcarbonyl-trans-2,5-bis(methoxymethoxymethyl)pyrrolidine 
• 115378-72-8 (2R,5R)-N-benzoylcarbonyl-trans-2,5-bis(methoxymethoxymethyl)pyrrolidine 
• 2999-74-8 dimethylmagnesium 
• 100-58-3 phenylmagnesium bromide 
• 917-54-4 methyllithium 
• 591-51-5 phenyllithium 
• 75-16-1 methylmagnesium bromide 

Relevant articles and documents

Diastereoselective Addition of Organometallics to N-(α-Ketoacyl)-trans-2,5-bis(methoxymethoxymethyl)pyrrolidine

The nucleophilic addition of organometallics to α-keto amides having (2R,5R)-trans-2,5-bis(methoxymethoxymethyl)pyrrolidine as a chiral auxiliary was studied and it was found that the sense and degree of diastereoselection strongly depended on organometallics and the reaction conditions used and that the diastereomeric hydroxy amides was obtained with high stereoselectivity by the choice of appropriate reaction conditions.