1269795-88-1Relevant articles and documents
Domino condensation/s-arylation/heterocyclization reactions: Copper-catalyzed three-component synthesis of 2-n-substituted benzothiazoles
Ma, Dawei,Lu, Xu,Shi, Liu,Zhang, Hui,Jiang, Yongwen,Liu, Xiangqian
, p. 1118 - 1121 (2011)
All in it together: A highly efficient and extremely versatile method for the assembly of benzothiazoles with a nitrogen substituent in the 2-position relies on a copper-catalyzed cascade reaction of a 2-haloaniline, carbon disulfide, and an N nucleophile (see scheme). The products are useful precursors for the synthesis of a range of important pharmaceutical agents. DMF=N,N-dimethylformamide; R,R=H, alkyl, aryl; Z=Me, CF3, CO 2Me, CN, N2O, Cl, F, Ac.