127-27-5 Usage
Description
Pimaric acid is a resin acid that has been found in A. cordata and various pines. It possesses the ability to reduce mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) in a concentration-dependent manner. Pimaric acid also has the capability to reduce nuclear expression and binding of transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs, as well as reduce TNF-α-induced HASMC migration to control levels.
Uses
Used in Pharmaceutical Industry:
Pimaric acid is used as a novel activator of large-conductance Ca2+-activated K+ channel α-subunit for its potential therapeutic applications.
Used in Cardiovascular Research:
Pimaric acid is used as a regulator of matrix metalloproteinase-9 (MMP-9) expression and activity in human aortic smooth muscle cells (HASMCs) for its potential role in cardiovascular health and disease prevention.
Used in Anti-inflammatory Applications:
Pimaric acid is used to reduce the nuclear expression and binding of transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs, which may contribute to its anti-inflammatory properties.
Used in Cell Migration Studies:
Pimaric acid is used to reduce TNF-α-induced HASMC migration to control levels, which may have implications for understanding and treating conditions involving abnormal cell migration.
Check Digit Verification of cas no
The CAS Registry Mumber 127-27-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 7 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 127-27:
(5*1)+(4*2)+(3*7)+(2*2)+(1*7)=45
45 % 10 = 5
So 127-27-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,13,15-16H,1,6-12H2,2-4H3,(H,21,22)/t15-,16+,18+,19+,20+/m0/s1
