127199-45-5Relevant articles and documents
Method for (7S)-5- synthesizing [2.4] tert -7-butyl carbamic acid tert-butyl (by machine translation)
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, (2019/12/02)
To the preparation method disclosed by the invention (7S) - 5 - [2.4] the raw materials are easily available, the process is simple, the (>99.0% ee) optical purity of the obtained product is high, and the method is suitable for industrial large-scale production. The invention provides a novel method for synthesizing a spirocyclic intermediate of sitafloxacin. (by machine translation)
Preparation method of sitafloxacin key intermediate
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Paragraph 0061-0066; 0070, (2018/04/26)
The invention discloses a preparation method of a sitafloxacin key intermediate, namely a preparation method of (7S)-t-butyloxycarboryl amino-5-azaspiro[2,4] heptane. By taking (7S)-t-butyloxycarborylamino-5-N-benzyl azaspiro[2,4] heptane as a raw material, the (7S)-t-butyloxycarboryl amino-5-azaspiro[2,4] heptane is obtained by means of devitrification after a reaction by taking palladium carbonas a catalyst and ammonium formate as a hydrogen source in an alcohol solvent. The method is simple to operate and mild in reaction, solves the problem that the triatomic ring on the spiral ring is opened successively, and meanwhile, can obtain the sitafloxacin key intermediate which is high in purity. The sitafloxacin obtained by the follow-up process is few in impurity, high in purity and suitable for the demand on industrial production.
Processes for preparation of bicyclic compounds and intermediates therefor
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Page 33, (2010/02/05)
A process for preparing intermediate compound (VII), compound (VIII) and compound (XIV) which will be raw materials for the synthesis of a synthetic antibactrial compound, via compound (I) or compound (X) and then, compound (II), the compounds each being shown below; and novel compounds useful for the preparation.