127300-01-0

Basic information

• Product Name: 1-propyl-4-(3,3,3-trifluoroprop-1-yn-1-yl)benzene
• Synonyms: 1-propyl-4-(3,3,3-trifluoroprop-1-yn-1-yl)benzene
• CAS NO: 127300-01-0
• Molecular Weight: 212.215
• Mol File: 127300-01-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-propyl-4-(3,3,3-trifluoroprop-1-yn-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-propyl-4-(3,3,3-trifluoroprop-1-yn-1-yl)benzene(127300-01-0)
• EPA Substance Registry System: 1-propyl-4-(3,3,3-trifluoroprop-1-yn-1-yl)benzene(127300-01-0)

Safety Data

• Hazardous Substances Data: 127300-01-0(Hazardous Substances Data)

Upstream product

• 1415023-66-3 C₁₁H₁₁BF₃^(1-)*K⁽¹⁺⁾ 
• 2926-29-6 Langlois reagent 
• 62452-73-7 1-ethynyl-4-propylbenzene 
• 147531-11-1 trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt 
• 887144-97-0 Togni's reagent 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Relevant articles and documents

Copper-mediated trifluoromethylation of potassium alkynyltrifluoroborates with Langlois' reagent Dedicated to Professor Pierre Vogel on the occasion of his 70th birthday

Synthesis of trifluoromethylated acetylenes by copper-mediated trifluoromethylation of potassium alkynyltrifluoroborates with CF3 radicals generated from NaSO2CF3 and tert-butyl hydroperoxide (TBHP) is communicated. The trifluoromethylated acetylenes were obtained in good to moderate yields. The presented method tolerates a wide range of aromatic, heteroaromatic, and aliphatic potassium alkynyltrifluoroborates.

Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

A catalytic process for trifluoromethylation of terminal alkynes with Togni's reagent has been developed, affording trifluoromethylated acetylenes in good to excellent yields. The reaction is conducted at room temperature and exhibits tolerance to a range

Copper-mediated aerobic oxidative trifluoromethylation of terminal alkynes with Me3SiCF3

An efficient copper-mediated trifluoromethylation of terminal alkynes with nucleophilic trifluoromethylating reagent (Me3SiCF3) was developed. Both aromatic alkynes and aliphatic alkynes were effective, and a variety of functionalities such as amino, -OMe, -CO2Et, -Br, and -NO2 were tolerated under the reaction conditions. This reaction provides a general, straightforward, and practically useful method to prepare trifluoromethylated acetylenes.