127343-08-2Relevant articles and documents
3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 7. Modification of the Hexahydronaphthalene Moiety of Simvastanin: 5-Oxygenated and 5-Oxa Derivatives
Duggan, Mark E.,Alberts, Alfred W.,Bostedor, Rick,Chao, Yu-sheng,Germershausen, John I.,et al.
, p. 2489 - 2495 (2007/10/02)
Modification of the hexahydronaphthalene ring 5-position in simvastatin 2a via oxygenation and oxa replacement afforded two series of derivatives which were evaluated in vitro for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme.A reductase and acutely i
5-oxygenated HMG-CoA reductase inhibitors
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, (2008/06/13)
Novel HMG-CoA reductase inhibitors are useful as antihypercholesterolemic agents and are represented by structural formulae (I) or (II): STR1 wherein position 5 of the polyhydronaphthyl ring is singly or doubly bonded to oxygen or incorporated into a C3-7 carbocyclic ring.