1273578-50-9

Basic information

• Product Name: N-benzyl-3-(4-methylphenyl)-2-propynylamine
• Synonyms: N-benzyl-3-(4-methylphenyl)-2-propynylamine
• CAS NO: 1273578-50-9
• Molecular Weight: 235.329
• Mol File: 1273578-50-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-benzyl-3-(4-methylphenyl)-2-propynylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-3-(4-methylphenyl)-2-propynylamine(1273578-50-9)
• EPA Substance Registry System: N-benzyl-3-(4-methylphenyl)-2-propynylamine(1273578-50-9)

Safety Data

• Hazardous Substances Data: 1273578-50-9(Hazardous Substances Data)

Upstream product

• 130024-90-7 4-(3-bromoprop-1-ynyl)toluene 
• 100-46-9 benzylamine 
• 4626-58-8 benzyl(but-2-yn-1-yl)amine 
• 766-97-2 4-n-methylphenylacetylene 
• 40032-57-3 N-(3-phenylprop-2-ynyl)benzenemethanamine 
• 1197-51-9 N-propargylbenzylamine 
• 624-31-7 4-tolyl iodide 

Downstream Products

• 1273578-25-8 1-methyl-1H-indole-2-carboxylic acid benzyl-(3-p-tolyl-prop-2-ynyl)-amide 
• 1273578-37-2 2-benzyl-10-methyl-5-p-tolyl-3,10-dihydro-2H-azepino[3,4-b]indol-1-one 
• 1273578-49-6 C₂₇H₂₄N₂O 
• 40032-57-3 N-(3-phenylprop-2-ynyl)benzenemethanamine 
• 766-97-2 4-n-methylphenylacetylene 
• 1379038-80-8 N-benzylhept-2-yn-1-amine 
• 1373169-44-8 (1-benzyl-2-phenyl-1H-imidazol-4-yl)(p-tolyl)methanone 
• 1373169-40-4 N-benzyl-N-(3-(p-tolyl)prop-2-yn-1-yl)benzimidamide 

Relevant articles and documents

One-pot, two-step synthesis of 7-methylene-1,5-piperazine-fused 1,2,3-triazoles

A facile, one-pot two-step synthesis of 7-methylene-1,5-piperazine-fused 1,2,3-triazole derivatives has been developed. The protocol employs an N-allylation of N-propargylated amines with 2,3-dibromopropene in the presence of K2CO3 in DMSO and a CuI-catalyzed [3 + 2] cycloaddition reaction of the synthetic N-(2-bromoallyl)-N-propargyl amines with sodium azide sequentially. Such a method provides methylene-substituted 1,2,3-triazole fused piperazines with some advantages such as simple operation, high efficiency and good product yield (80–91%) through readily available starting materials.

Lanthanide-Catalyzed Reversible Alkynyl Exchange by Carbon–Carbon Single-Bond Cleavage Assisted by a Secondary Amino Group

Lanthanide-catalyzed alkynyl exchange through C?C single-bond cleavage assisted by a secondary amino group is reported. A lanthanide amido complex is proposed as a key intermediate, which undergoes unprecedented reversible β-alkynyl elimination followed by alkynyl exchange and imine reinsertion. The in situ homo- and cross-dimerization of the liberated alkyne can serve as an additional driving force to shift the metathesis equilibrium to completion. This reaction is formally complementary to conventional alkyne metathesis and allows the selective transformation of internal propargylamines into those bearing different substituents on the alkyne terminus in moderate to excellent yields under operationally simple reaction conditions.

Platinum-catalyzed cyclization reaction of alkynes: Synthesis of azepino[3,4-b]indol-1-ones

Novel azepino[3,4-b]indol-1-ones were synthesized from alkyne-substituted indole-2-carboxamides by catalytic intramolecular cyclization in the presence of PtCl2. The scope and limitations of this straightforward protocol are reported.