1274038-52-6 Usage
Description
1-((4-methoxybenzyloxy)methyl)-3-bromobenzene is an organic compound characterized by a benzene ring with a bromine atom at the 3-position and a methoxybenzyl ether at the 1-position. The methoxybenzyl ether is a functional group that features a methoxy group attached to a benzyl group, which is then connected to the benzene ring through an ether linkage. 1-((4-methoxybenzyloxy)methyl)-3-bromobenzene is known for its utility in organic synthesis, where it serves as a reagent or intermediate for creating a variety of other organic compounds. Careful handling and adherence to safety protocols are essential when working with this chemical in a laboratory environment.
Uses
Used in Organic Synthesis:
1-((4-methoxybenzyloxy)methyl)-3-bromobenzene is used as a reagent in the field of organic synthesis for the preparation of various other organic compounds. Its unique structure allows for a range of chemical reactions, making it a valuable component in the synthesis of diverse molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-((4-methoxybenzyloxy)methyl)-3-bromobenzene is used as an intermediate in the development of new drugs. Its specific functional groups can be manipulated to create molecules with potential therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Chemical Research:
1-((4-methoxybenzyloxy)methyl)-3-bromobenzene is also utilized in chemical research as a model or reference molecule for studying various reaction mechanisms and understanding the behavior of similar organic compounds. It can provide insights into the reactivity and stability of related structures, furthering the knowledge in the field of chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1274038-52-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,7,4,0,3 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1274038-52:
(9*1)+(8*2)+(7*7)+(6*4)+(5*0)+(4*3)+(3*8)+(2*5)+(1*2)=146
146 % 10 = 6
So 1274038-52-6 is a valid CAS Registry Number.
1274038-52-6Relevant articles and documents
Synthesis and structure activity relationships of carbamimidoylcarbamate derivatives as novel vascular adhesion protein-1 inhibitors
Yamaki, Susumu,Yamada, Hiroyoshi,Nagashima, Akira,Kondo, Mitsuhiro,Shimada, Yoshiaki,Kadono, Keitaro,Yoshihara, Kosei
, p. 6024 - 6038 (2017)
Vascular adhesion protein-1 (VAP-1) is a promising therapeutic target for the treatment of diabetic nephropathy. Here, we conducted structural optimization of the glycine amide derivative 1, which we previously reported as a novel VAP-1 inhibitor, to improve stability in dog and monkey plasma, and aqueous solubility. By chemical modification of the right part in the glycine amide derivative, we identified the carbamimidoylcarbamate derivative 20c, which showed stability in dog and monkey plasma while maintaining VAP-1 inhibitory activity. We also found that conversion of the pyrimidine ring in 20c into saturated rings was effective for improving aqueous solubility. This led to the identification of 28a and 35 as moderate VAP-1 inhibitors with excellent aqueous solubility. Further optimization led to the identification of 2-fluoro-3-{3-[(6-methylpyridin-3-yl)oxy]azetidin-1-yl}benzyl carbamimidoylcarbamate (40b), which showed similar human VAP-1 inhibitory activity to 1 with improved aqueous solubility. 40b showed more potent ex vivo efficacy than 1, with rat plasma VAP-1 inhibitory activity of 92% at 1 h after oral administration at 0.3 mg/kg. In our pharmacokinetic study, 40b showed good oral bioavailability in rats, dogs, and monkeys, which may be due to its improved stability in dog and monkey plasma.
