127464-60-2

Basic information

• Product Name: HUMAN VEGF165
• Synonyms: HUMAN GLIOMA-DERIVED ENDOTHELIAL CELL MITOGEN;HUMAN VEGF;HUMAN VEGF121;HUMAN VEGF165;HUMAN VAS;HUMAN VASCULAR ENDOTHELIAL CELL GROWTH FACTOR;HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR (121 AA);HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR (165 AA)
• CAS NO: 127464-60-2
• Molecular Formula: NULL
• Molecular Weight: 0
• Product Categories: monoclonal antibody
• Mol File: 127464-60-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /powder
• Storage Temp.: −20°C
• CAS DataBase Reference: HUMAN VEGF165(CAS DataBase Reference)
• NIST Chemistry Reference: HUMAN VEGF165(127464-60-2)
• EPA Substance Registry System: HUMAN VEGF165(127464-60-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 127464-60-2(Hazardous Substances Data)

Usage

Description

HUMAN VEGF165, also known as vascular endothelial growth factor, is a 38.2kDa disulfide-linked homodimeric protein derived from human sources. It consists of two 165 amino acid polypeptide chains and signals through three receptors: fms-like tyrosine kinase (flt-1), KDR gene product, and the flt4 gene product. This protein plays a crucial role in various biological processes, including angiogenesis, cell proliferation, and vascular permeability.

Uses

Used in Cell Biology Research:
HUMAN VEGF165 is used as a chemoattractant for HUVECs (human umbilical vein endothelial cells) migration assay. This application is essential for studying the migration and proliferation of endothelial cells, which are vital for understanding the processes of angiogenesis and vascular development.
Used in Pharmaceutical Industry:
HUMAN VEGF165 is used as a target for the development of therapeutic agents aimed at treating various diseases, including cancer, age-related macular degeneration, and diabetic retinopathy. By targeting VEGF, these therapeutic agents can inhibit angiogenesis, which is a critical process for tumor growth and metastasis.
Used in Diagnostic Applications:
HUMAN VEGF165 can be employed in the development of diagnostic tools and assays to measure the levels of VEGF in biological samples. This can help in the early detection and monitoring of diseases where VEGF levels are elevated, such as cancer and certain eye disorders.
Used in Tissue Engineering and Regenerative Medicine:
HUMAN VEGF165 can be utilized in tissue engineering and regenerative medicine applications to promote the growth of new blood vessels and improve the vascularization of engineered tissues. This can enhance the success of tissue grafts and improve the healing process in various medical conditions.

Biochem/physiol Actions

VEGF (vascular endothelial growth factor) is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intraocular neovascular syndromes. Polymorphism in VEGF at C(-634)G is linked with diabetic retinopathy in type 2 diabetes.

Related news

Expression of HUMAN VEGF165 (cas 127464-60-2) in silkworm (Bombyx mori L.) by using a recombinant baculovirus and its bioactivity assay08/11/2019

Silkworm larva has a lot of advantages as a “biofactory” to produce recombinant protein. A recombinant baculovirus, carrying cDNA encoding the 165 amino-acid long isoform of human vascular endothelial growth factor (VEGF) was successfully constructed for the large-scale production of this prot...detailed