127492-00-6Relevant articles and documents
A New and Efficient Asymmetric Synthesis of an A-Ring Precursor to Physiologically Active 1α-Hydroxyvitamin D3 Steroids
Posner, Gary H.,Carry, Jean-Christophe,Anjeh, Tizah E. N.,French, Andrew N.
, p. 7012 - 7014 (1992)
A highly stereocontrolled and mild Diels-Alder cycloaddition involving stereochemically matched pyrone (S)-lactate 4 and Lewis acid (-)-Pr(hfc)3 produced bicyclic lactone endo-5 via a double stereodifferentiation process.Bicyclic lactone 5 was then transf
Binaphthol-titanium-promoted, highly enantiocontrolled, Diels-Alder cycloadditions of electronically matched 2-pyrones and vinyl ethers: Streamlined asymmetric synthesis of an A-ring precursor to physiologically active 1α-hydroxyvitamin D3 ster
Posner,Eydoux,Lee,Bull
, p. 7541 - 7544 (2007/10/02)
Bicyclic lactones 4, A-ring precursors to diverse physiologically active 1α-hydroxyvitamin D3 analogs, were prepared in excellent yields and enantiomeric purities via chiral, non-racemic Lewis acid-promoted, mild, inverse-electron-demand 4+2-cy