1276109-98-8

Basic information

• Product Name: N-(5-(imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)benzenesulfonamide
• CAS NO: 1276109-98-8
• Molecular Weight: 350.401
• Mol File: 1276109-98-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(5-(imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-(imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)benzenesulfonamide(1276109-98-8)
• EPA Substance Registry System: N-(5-(imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)benzenesulfonamide(1276109-98-8)

Safety Data

• Hazardous Substances Data: 1276109-98-8(Hazardous Substances Data)

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 1084-12-4 N-(5-bromopyridin-3-yl)benzenesulfonamide 
• 13535-01-8 3-amino-5-bromopyridine 
• 6188-23-4 6-bromoimidazo[1,2-a]pyridine 
• 1276109-89-7 C₁₂H₁₀N₄ 
• 1072-97-5 5-bromo-2-pyridylamine 

Relevant articles and documents

Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis

Phosphatidylinositol 3-kinase α (PI3Kα) is an important regulator of intracellular signaling pathways, controlling remarkably diverse arrays of physiological processes. Because the PI3K pathway is frequently up-regulated in human cancers, the inhibition of PI3Kα can be a promising approach to cancer therapy. In this study, we have designed and synthesized a new series of imidazo[1,2-a]pyridine derivatives as PI3Kα inhibitors through the fragment-growing strategy. By varying groups at the 3- and 6-positions of imidazo[1,2-a]pyridines, we studied the structure-activity relationships (SAR) profiles and identified a series of potent PI3Kα inhibitors. Representative derivatives showed good activity in cellular proliferation and apoptosis assays. Moreover, these inhibitors exhibited noteworthy antiangiogenic activity.