127680-54-0

Basic information

• Product Name: (1S,3R,5R,6R)-8-aza-3-<1-(S)-benzyloxyethyl>-5-methyl-2,4-dioxa-bicyclo<4.2.0>octan-7-one
• Synonyms: (1S,3R,5R,6R)-8-aza-3-<1-(S)-benzyloxyethyl>-5-methyl-2,4-dioxa-bicyclo<4.2.0>octan-7-one
• CAS NO: 127680-54-0
• Molecular Weight: 277.32
• Mol File: 127680-54-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1S,3R,5R,6R)-8-aza-3-<1-(S)-benzyloxyethyl>-5-methyl-2,4-dioxa-bicyclo<4.2.0>octan-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,3R,5R,6R)-8-aza-3-<1-(S)-benzyloxyethyl>-5-methyl-2,4-dioxa-bicyclo<4.2.0>octan-7-one(127680-54-0)
• EPA Substance Registry System: (1S,3R,5R,6R)-8-aza-3-<1-(S)-benzyloxyethyl>-5-methyl-2,4-dioxa-bicyclo<4.2.0>octan-7-one(127680-54-0)

Safety Data

• Hazardous Substances Data: 127680-54-0(Hazardous Substances Data)

Upstream product

• 130919-58-3 (2R,6R)-2-<1-(S)-benzyloxyethyl>-6-methyl-1,3-dioxan-4-ol 
• 127680-52-8 (2R,6R)-2-<1-(S)-benzyloxyethyl>-6-methyl-1,3-dioxan-4-one 
• 81445-44-5 (S)-2-(benzyloxy)propanal 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 127680-53-9 (2R,4R)2-<1-(S)-benzyloxyethyl>-4-methyl-2H,4H-1,3-dioxin 

Downstream Products

• 76899-07-5 (3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one 
• 87037-95-4 (3R,4R)-4-acetoxy-3-[(1R)-1-hydroxyethyl]azetidin-2-one 
• 114341-89-8 (3S,4R)-3-<(R)-1-(t-Butyldimethylsilyloxy)ethyl>-4-<(R)-1-(4,4-dimethyl-2-oxazolidone-3-carbonyl)ethyl>-2-azetidinone 

Relevant articles and documents

A NOVEL SYNTHESIS OF THE 1β-METHYLCARBAPENEM KEY INTERMEDIATE EMPLOYING THE -CYCLOADDITION REACTION OF CHLOROSULFONYL ISOCYANATE WITH A 4H-1,3-DIOXIN DERIVATIVE

A highly stereoselective synthetic route to the title compound was explored by featuring the -cycloaddition reaction of chlorosulfonyl isocyanate with the 4H-1,3-dioxin derivative readily obtainable from methyl (R)-3-hydroxybutyrate, the Baeyer-Villinger reaction resulting in novel cleavage of the acetal moiety, and the Reformatsky reaction with sterically crowded 3-(2-bromopropionyl)-2-oxazolidone derivatives.