1278406-12-4

Basic information

• Product Name: methyl 4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(1-methyl-1H-1,2,4-triazol-5-ylamino)pyrimidine-5-carboxylate
• CAS NO: 1278406-12-4
• Molecular Weight: 372.375
• Mol File: 1278406-12-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(1-methyl-1H-1,2,4-triazol-5-ylamino)pyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(1-methyl-1H-1,2,4-triazol-5-ylamino)pyrimidine-5-carboxylate(1278406-12-4)
• EPA Substance Registry System: methyl 4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(1-methyl-1H-1,2,4-triazol-5-ylamino)pyrimidine-5-carboxylate(1278406-12-4)

Safety Data

• Hazardous Substances Data: 1278406-12-4(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 
• 1278406-11-3 methyl 2-[⁽¹⁴⁾C]-2-chloro-4-(4-fluorophenyl)-6-isopropylpyrimidine-5-carboxylate 
• 15795-39-8 5-amino-1-methyl-1,2,4-triazole 

Downstream Products

• 1278406-13-5 methyl 4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carboxylate 
• 1278406-27-1 C₂₃⁽¹⁴⁾CH₂₇FN₆O₃ 
• 1278406-23-7 ammonium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate 
• 1278406-22-6 (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid 
• 1278406-20-4 tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate 
• 1278406-17-9 4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carboxaldehyde 
• 1278406-15-7 4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-ylmethanol 

Relevant articles and documents

Synthesis and stability of a carbon-14-labeled 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitor

Inhibition of 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR) is an effective method of lowering plasma low-density lipoprotein cholesterol levels. Hemi-calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H- 1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate (1) is a cholesterol-lowering statin drug that effectively inhibits HMGR. An important step in the development of this compound was the synthesis of a carbon-14-labeled analog for use in preclinical absorption, distribution, metabolism and excretion studies. The synthesis of a carbon-14-labeled analog of the cholesterol-lowering statin drug 1 is described. The carbon-14-labeled compound [14C]-1 was prepared in 11 steps from [14C]- labeled urea. The overall radiochemical yield for the synthesis was 22% and the radiochemical purity of [14C]-1 was 99.9% immediately after synthesis. It was found that [14C]-1 with a specific activity of 43.2μCi/mg decomposed at a rate of about 1.9%/month when stored at -78°C under argon. Three samples of [14C]-1 were prepared to study the chemical stability of the molecule. One sample had a specific activity of 3.8μCi/mg and the other two contained radical inhibitors, L-ascorbic acid (1% by weight, specific activity of 10.5μCi/mg) or BHT (1% by weight, specific activity of 9.8μCi/mg). For these samples the decomposition rates were decreased to 0.5%/month, 0.2%/month and 0.1%/month, respectively. Copyright