128071-86-3

Basic information

• Product Name: 2-Chloro-4-Bromo-3-Picoline
• Synonyms: 2-Chloro-4-Bromo-3-Picoline;4-Bromo-2-chloro-3-methylpyridine;4-bromo-2-chloropicoline;Pyridine, 4-broMo-2-chloro-3-Methyl-
• CAS NO: 128071-86-3
• Molecular Formula: C₆H₅BrClN
• Molecular Weight: 206.4676
• Product Categories: Pyridine
• Mol File: 128071-86-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 249.7±35.0℃ (760 Torr)
• Flash Point: 104.8±25.9℃
• Appearance: /
• Density: 1.624±0.06 g/cm3 (20 ºC 760 Torr)
• Refractive Index: 1.571
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Chloro-4-Bromo-3-Picoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-Bromo-3-Picoline(128071-86-3)
• EPA Substance Registry System: 2-Chloro-4-Bromo-3-Picoline(128071-86-3)

Safety Data

• Hazardous Substances Data: 128071-86-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-Bromo-3-Picoline is a derivative of pyridine, featuring chlorine and bromine atoms as substituents at specific positions on the pyridine ring. 2-Chloro-4-Bromo-3-Picoline is mainly used in the chemical industry as a building block for the synthesis of more complex molecules, often in pharmaceutical or agrochemical products. Being a halogenated pyridine, it possesses reactivity which makes it a valuable intermediate in the production of certain drugs or speciality chemicals. Its presence in such products can contribute to their biological activity or modify their physical and chemical properties. Moreover, like other pyridines, it is able to act as a ligand in coordination chemistry, forming complexes with metals. However, due to its distinct structure, the safety and environmental implications of its use need to be considered carefully.

InChI:InChI=1/C6H5BrClN/c1-4-5(7)2-3-9-6(4)8/h2-3H,1H3

Upstream product

• 52200-48-3 3-bromo-2-chloropyridine 
• 74-88-4 methyl iodide 
• 73583-37-6 2-chloro-4-bromopyridine 

Downstream Products

• 1334589-85-3 methyl 3-(4-((2-chloro-3-methylpyridin-4-yl)ethynyl)phenyl)-propanoate 
• 1334589-72-8 3-(4-((2-chloro-3-methylpyridin-4-yl)ethynyl)phenyl)propanoic acid 

Relevant articles and documents

Pyrimidine or pyridine pyridine ketone compound and its preparation method and application (by machine translation)

The invention discloses a kind of type I of the pyrimidine or pyridine pyridine ketone compound and its preparation and application, which belongs to the technical field of pharmaceutical preparation. The compounds have high-efficient and selectively inhibit the cell cycle dependent kinases (Cdks) CDK4 and CDK6 active, and then by inhibiting CDK4/CDK6 prevent tumor cell division. Therefore, the compounds of this invention can be used for CDK4 and CDK6 the involved in cell cycle control disorders result in various diseases, especially suitable for the treatment of malignant tumors. (by machine translation)

Migration du lithium en serie pyridinique: double catalyse et reformage. Acces aux derives de la bromo-2 lithio-3 pyridine et des bromo-4 halogeno-2 lithio-3 pyridines

The lithium of an organolithium-pyridinic derivative can be moved from one position to an another by an intermolecular reaction.Two new reactions are possible for pyridinic organic synthesis: the isomerisation of any lithio derivative to a more stable one, and a reaction that transforms a mixture of various bromo-lithio derivatives into a single one.The processes involved and the experimental tools used are described in terms of the 2-bromo-3-lithio- and 4-bromo-2-halogeno-3-lithiopyridines derivatives synthesis.