1281902-53-1Relevant articles and documents
Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach
M?cklinghoff, Sabine,Van Otterlo, Willem A. L.,Rose, Rolf,Fuchs, Sascha,Zimmermann, Tobias J.,Dominguez Seoane, Marta,Waldmann, Herbert,Ottmann, Christian,Brunsveld, Luc
, p. 2005 - 2011 (2011)
A library of small tetrahydroisoquinoline ligands, previously identified via structure- and chemistry-based hierarchical organization of library scaffolds in tree-like arrangements, has been generated as novel estrogen receptor agonistic fragments via traditional medicinal chemistry exploration. The approach described has allowed for the rapid evaluation of a structure-activity relationship of the ligands concerning estrogen receptor affinity and estrogen receptor - subtype selectivity. The structural biological insights obtained from the fragments aid the understanding of larger analogues and constitute attractive starting points for further optimization.
