128200-58-8Relevant articles and documents
Synthesis of some amino and carboxy analogs of galabiose; evaluation as inhibitors of the pilus protein PapG(J)96 from Escherichia coli
Hansen, Henrik C.,Magnusson, Goeran
, p. 233 - 242 (2007/10/03)
The 2'-amino-2'-deoxy, 6-amino-6-deoxy, and 6-carboxy analogs of the reference inhibitor 2(trimethylsilyl)ethyl (α-D-galactopyranosyl)-(1→4)- β-d-galactopyranoside were synthesized and evaluated as inhibitors of the binding of the Escherichia coli-derived pilus protein PapG(J96), using an ELISA assay. The inhibitory efficiencies (K(rel); relative to the reference inhibitor) were: 157, 13, and 8, respectively. The results support the previously proposed combining site model, where the protein carries a negatively charged amino acid residue near HO-2' and HO-6 of the galabioside.
METHOD FOR TREATING GALABIOSE-BINDING BACTERIA INFECTIONS
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, (2008/06/13)
A method for treating infections caused by galabiose-binding bacteria using galabiose derivatives modified at the 3 and anomeric positions. The galabiose-derivatives and compositions of some are also disclosed