128322-44-1

Basic information

• Product Name: MCLA
• Synonyms: MCLA;MCLA, HYDROCHLORIDE;CYPRIDINA LUCIFERIN METHOXY-ANALOGUE;2-METHYL-6-(4-METHOXYPHENYL)-3,7-DIHYDROIMIDAZO[1,2-A]PYRAZIN-3(7H)-ONE HYDROCHLORIDE;2-METHYL-6-(4-METHOXYPHENYL)-3,7-DIHYDROIMIDAZO[1,2-A]PYRAZIN-3-ONE HYDROCHLORIDE;6-(4-METHOXYPHENYL)-2-METHYL-3,7-DIHYDROIMIDAZO[1,2-A]PYRAZIN-3(7H)-ONE HYDROCHLORIDE;6-(4-METHOXYPHENYL)-2-METHYL-3,7-DIHYDROIMIDAZO[1,2-A]PYRAZIN-3-ONE HYDROCHLORIDE;6-(4-MEOPHE.)-2-ME-3,7-DIHYDROIMIDAZO(A)PYRAZIN-3(7H)-ON-HCL
• CAS NO: 128322-44-1
• Molecular Formula: C₁₄H₁₃N₃O₂*ClH
• Molecular Weight: 291.73
• Product Categories: Analytical Chemistry;Chemiluminescence;Cypridina Luciferin Analog
• Mol File: 128322-44-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 410.3 °C at 760 mmHg
• Flash Point: 201.9 °C
• Appearance: /
• Vapor Pressure: 3.95E-07mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: DMSO: soluble
• BRN: 5838857
• CAS DataBase Reference: MCLA(CAS DataBase Reference)
• NIST Chemistry Reference: MCLA(128322-44-1)
• EPA Substance Registry System: MCLA(128322-44-1)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 128322-44-1(Hazardous Substances Data)

Usage

Description

MCLA, or 12-(7-methly-4-oxo-4H-chromen-3-yl) laurate, is a potent chemiluminescent probe that is commonly used in the detection of superoxide generated by activated leukocytes and macrophages. It is a valuable tool in the study of various biological processes and has potential applications in different industries.

Uses

Used in Biomedical Research:
MCLA is used as a detection agent for superoxide generated by activated leukocytes and macrophages. It is particularly useful in the study of immune responses and the role of superoxide in various diseases.
Used in Diagnostic Applications:
MCLA is used as a diagnostic tool to detect the presence of superoxide in biological samples. Its chemiluminescent properties allow for the detection of superoxide at near 654 nm, making it a valuable tool in the diagnosis of various conditions related to oxidative stress.
Used in Pharmaceutical Development:
MCLA is used as a research compound in the development of new drugs targeting superoxide production and related pathways. Its ability to detect superoxide makes it a useful tool in the screening and evaluation of potential therapeutic agents.
Used in Environmental Monitoring:
MCLA can be used as a monitoring agent to detect the presence of superoxide in the environment, which can be useful in assessing the impact of pollutants and other factors on the oxidative state of ecosystems.

InChI:InChI=1/C14H13N3O2.ClH/c1-9-14(18)17-8-12(15-7-13(17)16-9)10-3-5-11(19-2)6-4-10;/h3-8,15H,1-2H3;1H

Upstream product

• 119738-50-0 2-amino-5-(4'-methoxyphenyl)-1,4-pyrazine 
• 78-98-8 2-oxopropanal 

Relevant articles and documents

Imidazolopyrazinones as potential antioxidants

A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine, a natural substrate of marine bioluminesc