1283751-57-4

Basic information

• Product Name: 6-chloro-2-phenyl-4-(2-fluorophenyl)quinazoline
• Synonyms: 6-chloro-2-phenyl-4-(2-fluorophenyl)quinazoline
• CAS NO: 1283751-57-4
• Molecular Weight: 334.78
• Mol File: 1283751-57-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-chloro-2-phenyl-4-(2-fluorophenyl)quinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-phenyl-4-(2-fluorophenyl)quinazoline(1283751-57-4)
• EPA Substance Registry System: 6-chloro-2-phenyl-4-(2-fluorophenyl)quinazoline(1283751-57-4)

Safety Data

• Hazardous Substances Data: 1283751-57-4(Hazardous Substances Data)

Upstream product

• 100-47-0 benzonitrile 
• 784-38-3 2-amino-5-chloro-2'-fluorobenzophenone 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Lewis-Acid-Catalysed Activation of Nitriles: A Microwave-Assisted Solvent-Free Synthesis of 2,4-Disubstituted Quinazolines and 1,3-Diazaspiro[5.5]undec-1-enes

Two different modes of cyclization take place to synthesize quinazoline, quinazolinone, and 1,3-diazaspiro[5.5]undec-1-ene derivatives through the Lewis-acid-catalysed activation of both aliphatic and aromatic nitriles in a single-step, solvent-free, and transition-metal-free reaction. An amidine is expected to form as an intermediate; this then undergoes intramolecular cyclization in a one-pot reaction sequence. The reaction is carried out under microwave irradiation using trimethylsilyltrifluoromethane sulfonate (TMSOTf) as a catalyst and nitriles as a nitrogen source with the respective reaction partners.

Microwave-promoted efficient synthesis of dihydroquinazolines

A solvent- and catalyst-free synthesis of dihydroquinazolines is described. 2,4-Disubstituted-1,2-dihydroquinazolines can be readily obtained from 2-aminobenzophenone and aldehydes under microwave irradiation using urea as an environmentally benign source