128486-54-4

Basic information

• Product Name: Lurosetron
• Synonyms: Lurosetron;Lurosetron [inn:ban]
• CAS NO: 128486-54-4
• Molecular Formula: C17H17FN4O
• Molecular Weight: 312.346
• Mol File: 128486-54-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 650.1°C at 760 mmHg
• Flash Point: 347°C
• Appearance: /
• Density: 1.4g/cm³
• Vapor Pressure: 8.76E-17mmHg at 25°C
• Refractive Index: 1.693
• PKA: 14.01±0.10(Predicted)
• CAS DataBase Reference: Lurosetron(CAS DataBase Reference)
• NIST Chemistry Reference: Lurosetron(128486-54-4)
• EPA Substance Registry System: Lurosetron(128486-54-4)

Safety Data

• Hazardous Substances Data: 128486-54-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H17FN4O/c1-10-13(20-9-19-10)8-22-7-6-14-15(17(22)23)11-4-3-5-12(18)16(11)21(14)2/h3-5,9H,6-8H2,1-2H3,(H,19,20)

Upstream product

• 84-58-2 2,3-dicyano-5,6-dichloro-p-benzoquinone 
• 6192-52-5 p-toluenesulfonic acid monohydrate 
• 38585-62-5 4-hydroxymethyl-5-methylimidazole hydrochloride 
• 128487-32-1 6-Fluoro-2,3,4,5-tetrahydro-5-methyl-2-[(4-methyloxazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one 
• 128487-40-1 4-[(6-Fluoro-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-pyrido[4,3-b]indol-2-yl)-methyl]-N,N,5-trimethyl-1H-imidazole-1-sulphonamide 
• 128487-42-3 6-fluoro-2,3,4,5-tetrahydro-2-[[1-(methoxymethyl)-4-methyl-1H-imidazol-5-yl]methyl]-5-methyl-1H-pyrido[4,3-b]indol-1-one 
• 128486-81-7 6-fluoro-2,5-dihydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one 
• 128487-43-4 phenylmethyl 4-[(6-fluoro-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-pyrido [4,3-b]indol-2-yl)methyl]-5-methyl-1H-imidazole-1-carboxylate 

Relevant articles and documents

LACTAM DERIVATIVES

The invention provides potent and selective antagonists of 5-HT at 5-HT 3 receptors which are tricyclic lactams of the formula (I) STR1 wherein Im represents an imidazolyl group of the formula: STR2 and R. sup.1 represents a hydrogen atom or a group selected from C 1-6 alkyl, C. sub.3-6 alkenyl, C 3-10 alkynyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, phenyl, phenylC 1-3 alkyl,--CO 2 R. sup.5,--COR 5,--CONR 5 R 6 or--SO 2 R 5 ;one of the groups represented by R 2, R. sup.3 and R 4 is a hydrogen atom or a C 1-6 alkyl, C 3-7 cycloalkyl, C 3-6 alkenyl, phenyl or phenylC 1-3 alkyl group, and each of the other two groups, which may be same or different, represents a hydrogen atom or a C 1-6 alkyl group;Y represents the group CH=CH or (CH 2) n, wherein n represents 2 or 3;Q represents a halogen atom, or a group selected from hydroxy, C 1-4 alkoxy, phenylC 1-3 alkoxy, C 1-6 alkyl, cyano, phenyl which may be unsubstituted or substituted by one or more C 1-4 alkyl, C 1-4 alkoxy or hydroxy groups or halogen atoms,--NR 7 R 8,--CONR 7 R. sup.8 ,--(CH 2) p CONR 7 R 8,--(CH 2) q NR 9 R 10 or--(CH 2) 2 CO 2 R 11 ;Q' represents a hydrogen or a fluorine atom;and physiologically acceptable salts and solvates thereof.