128924-00-5

Basic information

• Product Name: Benzene, 1,3-dichloro-5-(phenylmethoxy)-
• CAS NO: 128924-00-5
• Molecular Formula: C13H10Cl2O
• Molecular Weight: 253.128
• Mol File: 128924-00-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 1,3-dichloro-5-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,3-dichloro-5-(phenylmethoxy)-(128924-00-5)
• EPA Substance Registry System: Benzene, 1,3-dichloro-5-(phenylmethoxy)-(128924-00-5)

Safety Data

• Hazardous Substances Data: 128924-00-5(Hazardous Substances Data)

Upstream product

• 33719-74-3 3,5-dichloroanisole 
• 100-44-7 benzyl chloride 
• 591-35-5 3,5-dichlorophenol 
• 100-39-0 benzyl bromide 
• 618-62-2 3,5-dichloro-1-nitrobenzene 
• 100-51-6 benzyl alcohol 

Downstream Products

• 871339-85-4 1,1-dimethylethyl 4-(3-chloro-5-{[2-(diethylamino)ethyl]oxy}phenyl)piperazine-1-carboxylate 
• 871339-86-5 2-[(3-chloro-5-piperazin-1-ylphenyl)oxy]-N,N-diethylethanamine 
• 871339-84-3 1,1-dimethylethyl 4-(3-chloro-5-hydroxyphenyl)piperazine-1-carboxylate 
• 871339-83-2 3-chloro-5-piperazin-1-ylphenol 
• 1027961-23-4 4-(5-{[(R)-1-(3-Chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-2-fluoro-benzonitrile 
• 1027406-90-1 [1-(3-benzyloxy-5-chloro-benzylcarbamoyl)-3-methylsulfanyl-propyl]-carbamic acid tert-butyl ester 
• 1025906-75-5 [1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester 
• 53985-44-7 3-(benzyloxy)-5-chlorobenzoic acid 
• 871339-82-1 tert-butyl 4-[3-(benzyloxy)-5-chlorophenyl]piperazine-1-carboxylate 

Relevant articles and documents

PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS

New pyrazolopyridmiin-2-yl derivatives are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

KINASE MODULATORS AND METHODS OF USE

The present invention relates to compounds of the Formula I and II wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Inhibitors of prenyl-protein transferase

The present invention is directed to macrocyclic compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemothera-peutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.