129-17-9

Basic information

• Product Name: Acid blue 1
• Synonyms: 1085blue;4,4’-di(diethylamino)-4’,6’-disulphotriphenylmethanolanhydride,sodiumsalt;abcolpatentbluevf;acidbrightazurez;acidbrilliantbluevf;acidbrilliantbluez;acidbrilliantskybluez;acidleatherbluev
• CAS NO: 129-17-9
• Molecular Formula: C₂₇H₃₁N₂O₆S₂*Na
• Molecular Weight: 566.66
• EINECS: 204-934-1
• Product Categories: Triphenylmethane
• Mol File: 129-17-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: >250°C
• Appearance: Dark bluish-green to dark purple/Crystalline Powder
• Density: 0.392[at 20℃]
• Vapor Pressure: 0Pa at 25℃
• Storage Temp.: Storage temperature: no restrictions.
• Solubility: H2O: soluble1mg/mL
• Water Solubility: 1 g/20 mL (20 ºC)
• Stability: Stable. Incompatible with strong oxidizing agents.
• Merck: 13,9078
• BRN: 4108121
• CAS DataBase Reference: Acid blue 1(CAS DataBase Reference)
• NIST Chemistry Reference: Acid blue 1(129-17-9)
• EPA Substance Registry System: Acid blue 1(129-17-9)

Safety Data

• Hazard Codes: T
• Statements: 45
• Safety Statements: 24/25-53-45
• WGK Germany: 3
• RTECS: BP6830000
• Hazardous Substances Data: 129-17-9(Hazardous Substances Data)

Usage

Description

Acid blue 1 is an organic dye that is characterized by its dark greenish-black powder form. It is a polysulfated aromatic dye known for its colorful green light blue appearance. It is soluble in water at room temperature without any tendency to gather, and it exhibits a blue color when dissolved in ethanol. The dye also has good levelness and is used in various applications across different industries.

Uses

Used in Electron Microscopy and Fluorescence Research:
Acid blue 1 is used as a double labeled product for electron microscopy and fluorescence research, allowing for the visualization and analysis of cellular structures and processes.
Used in Medical Applications:
Patent Blue VF, a derivative of Acid blue 1, has been used in combination with 99mTc phytate to detect sentinel lymph nodes (SLN) in early-stage cervical cancer patients. It has also been used to detect heat shock protein (HSP) gp96 induced draining lymph nodes (LNs) in mice and to study the effect of Asn-Gly-Arg (NGR)-tumor necrosis factor (TNF) on tumor perfusion in a murine model.
Used in Ink Jet Textile Printing:
Acid blue 1 is used as an organic dye in ink jet textile printing, providing vibrant and long-lasting colors on fabrics.
Used in Dye Manufacturing:
Acid blue 1 is used in the production of carbon paper, ink, and color break, as well as for dyeing leather.
Properties and Applications:
Acid blue 1 exhibits good solubility in water and ethanol, and it is known for its strong color and good levelness. It can be used in dyeing wool, silk, and blended fabrics, as well as in direct wool and silk printing. The dye also has various fastness properties, such as light fastness, soaping fastness, perspiration fastness, oxygen bleaching, and fastness to seawater, making it suitable for various applications.
Standard:
The fastness properties of Acid blue 1 are rated according to ISO and AATCC standards, with ratings ranging from 1 to 3, indicating its performance in different conditions.

Preparation

4-Formylbenzene-1,3-disulfonic acid and N,N-diethylbenzenamine (2 Moore) condensation and oxidation, and then turn it into sodium salt.

Air & Water Reactions

Water soluble.

Fire Hazard

Flash point data for Acid blue 1 are not available; Acid blue 1 is probably combustible.

Flammability and Explosibility

Nonflammable

Biochem/physiol Actions

Patent Blue VF dye is a violet colored powder. It has been used in cosmetic coloring.

Standard

Light Fastness

Fading

Stain

ISO

2

AATCC

1

InChI:InChI=1/C27H32N2O6S2.Na/c1-5-28(6-2)22-13-9-20(10-14-22)27(21-11-15-23(16-12-21)29(7-3)8-4)25-18-17-24(36(30,31)32)19-26(25)37(33,34)35;/h9-19H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1

Synthetic route

Alphazurine 2G (129-17-9) → patent blue VF sulfonyl chloride

Conditions	Yield
With trichlorophosphate at 0 - 20℃; for 72h; Inert atmosphere;	90%
With trichlorophosphate at 20℃; for 72h;

Alphazurine 2G (129-17-9) → sodium; 4-[(4-diethylamino-cyclohexa-2,5-dienylidene)-(4-diethylamino-phenyl)-methyl]-3-sulfo-benzenesulfonate

Conditions	Yield
In water Kinetics; Electrochemical reaction;

Alphazurine 2G (129-17-9) → C64H100N3O22PS2 (1310568-66-1)

Conditions	Yield
Multi-step reaction with 2 steps 1: trichlorophosphate / 72 h / 20 °C 2: dmap; triethylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere View Scheme

Alphazurine 2G (129-17-9) → C60H92N3O22PS2 (1310568-67-2)

Conditions	Yield
Multi-step reaction with 3 steps 1: trichlorophosphate / 72 h / 20 °C 2: dmap; triethylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 3: trimethylsilyl bromide / dichloromethane / 20 °C View Scheme

Alphazurine 2G (129-17-9) → C43H64N6O12S2

Conditions	Yield
Multi-step reaction with 2 steps 1.1: trichlorophosphate / 72 h / 0 - 20 °C / Inert atmosphere 2.1: triethylamine; dmap / dichloromethane / 0.25 h / 0 °C / Inert atmosphere 2.2: 16 h / 0 - 20 °C / Inert atmosphere View Scheme

Alphazurine 2G (129-17-9) → 2C27H31N2O6S2(1-)*Ba(2+)

Conditions	Yield
With barium(II) chloride dihydrate In water at 50℃; for 2h; Inert atmosphere;

Downstream Products

• 1310568-67-2 C₆₀H₉₂N₃O₂₂PS₂ 
• 1310568-66-1 C₆₄H₁₀₀N₃O₂₂PS₂