1293987-57-1Relevant articles and documents
Identification of Thieno[3,2- d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3
Cho, Hanna,Choi, Hwan Geun,Jeon, Eunhye,Kim, Nam Doo,Kim, Sunghoon,Kim, Younghoon,Kwon, Nam Hoon,Lee, Jiwon,Moon, Youngji,Ryu, Seongshick,Shin, Injae,Sim, Taebo,Song, Chiman,Yoon, Hojong
, p. 11934 - 11957 (2021/08/20)
Focal adhesion kinase (FAK) is overexpressed in highly invasive and metastatic cancers. To identify novel FAK inhibitors, we designed and synthesized various thieno[3,2-d]pyrimidine derivatives. An intensive structure-activity relationship (SAR) study led
2,7-SUBSTITUTED THIENO[3,2-D]PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS
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, (2011/05/06)
Disclosed are a 2,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comp