1293990-69-8Relevant articles and documents
1,4,2-Dioxazol-5-ones as Isocyanate Equivalents: Chemoselective Non-Metal-Catalyzed Carboxamidation of Indoles
Vala, Anand,Parmar, Deepa,Rayani, Rahul,Kusurkar, Rakesh,Guduru, Ramakrishna,Kaneriya, Uttam,Gondaliya, Uday,Parmar, Nirali,Soni, Jigar Y.
, (2022/02/21)
1,4,2-Dioxazol-5-ones are known to undergo decarboxylation under thermal conditions followed by Lossen s rearrangement to give isocyanates. Described herein is the in situ trapping of the isocyanates by indoles to give indole-3-carboxamides in good to exc
RhIII-Catalyzed C?H Activation of Aryl Hydroxamates for the Synthesis of Isoindolinones
Shaaban, Saad,Davies, Caitlin,Merten, Christian,Flegel, Jana,Otte, Felix,Strohmann, Carsten,Waldmann, Herbert
, p. 10729 - 10734 (2020/07/25)
RhIII-catalyzed C?H functionalization reaction yielding isoindolinones from aryl hydroxamates and ortho-substituted styrenes is reported. The reaction proceeds smoothly under mild conditions at room temperature, and tolerates a range of functional groups. Experimental and computational investigations support that the high regioselectivity observed for these substrates results from the presence of an ortho-substituent embedded in the styrene. The resulting isoindolinones are valuable building blocks for the synthesis of bioactive compounds. They provide easy access to the natural-product-like compounds, isoindolobenzazepines, in a one-pot two-step reaction. Selected isoindolinones inhibited Hedgehog (Hh)-dependent differentiation of multipotent murine mesenchymal progenitor stem cells into osteoblasts.
Rhodium(III)-Catalyzed Controllable C?H Bond Functionalization of Benzamides and Vinylidenecyclopropanes: A Directing Group Determined Reaction Pathway
Ji, Cheng,Xu, Qin,Shi, Min
supporting information, p. 974 - 983 (2017/03/27)
A controllable rhodium(III)-catalyzed C?H bond activation of benzamides and vinylidenecyclopropanes (VDCPs) by changing the directing group from C(O)NH–OPiv to C(O)NH–OBoc has been disclosed, affording two different major products in good yields under mild condition, respectively. The substrate scope has been investigated and a plausible reaction mechanism has been also proposed on the basis of previous literature. (Figure presented.).
