129451-35-0Relevant articles and documents
Studies on Reactions of Nucleoside H-Phosphonates with Bifunctional Reagents. Part 2. Stability of Nucleoside H-Phosphonate Diesters in the Presence of Amino Alcohols
Sobkowski, Michal,Stawinski, Jacek,Sobkowska, Anna,Kraszewski, Adam
, p. 1803 - 1808 (2007/10/02)
H-Phosphonate diesters undergo transesterification with amino alcohols to afford as primary products the mixed and symmetrical H-phosphonate esters.Alcohols react similarly but only in the presence of an external base or in basic solvent.The rate and the course of transesterification strongly depend on the reaction conditions, the reactivity of the H-phosphonate diester used, and the nature of the amino alcohol.