1295568-44-3

Basic information

• Product Name: 4-benzyl-3H-pyrrolo[2,3-c]quinoline
• Synonyms: 4-benzyl-3H-pyrrolo[2,3-c]quinoline
• CAS NO: 1295568-44-3
• Molecular Weight: 258.323
• Mol File: 1295568-44-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-benzyl-3H-pyrrolo[2,3-c]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-3H-pyrrolo[2,3-c]quinoline(1295568-44-3)
• EPA Substance Registry System: 4-benzyl-3H-pyrrolo[2,3-c]quinoline(1295568-44-3)

Safety Data

• Hazardous Substances Data: 1295568-44-3(Hazardous Substances Data)

Upstream product

• 52636-03-0 3-(2-nitrophenyl)-1H-pyrrole 
• 24347-60-2 2,5-dimethylhexane-2,3-diol 
• 1033282-26-6 3-(2-nitrophenyl)-1-(triisopropylsilyl)-1H-pyrrole 
• 577-19-5 2-nitrophenyl bromide 
• 1589-82-8 phenylmagnesium bromide 
• 233770-18-8 2-formyl-3-(o-nitrophenyl)-1-tosylpyrrole 
• 1126425-85-1 2-(1-(triisopropylsilyl)-1H-pyrrol-3-yl)aniline 
• 615-36-1 2-bromoaniline 
• 128676-84-6 (2-chloroquinolin-3-yl)boronic acid 
• 78105-37-0 2-chloro-3-nitroquinoline 
• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 122-78-1 phenylacetaldehyde 
• 78599-49-2 3-(2'-aminophenyl)pyrrole 
• 1393935-90-4 C₁₃H₁₄N₂O₄ 

Relevant articles and documents

Extending the utility of the bartoli indolization: Synthesis of marinoquinolines C and e

A short synthesis of marinoquinolines C and E has been achieved. The synthetic route involves an ipso nitration of an electron-deficient boronic acid, the first example of a Bartoli indolization on a nitroquinoline and Suzuki coupling between 2-chloropyrroloquinoline and two separate MIDA boronates. Georg Thieme Verlag Stuttgart · New York.

Total Syntheses of the 3 H-Pyrrolo[2,3- c]quinolone-Containing Alkaloids Marinoquinolines A-F, K, and Aplidiopsamine A Using a Palladium-Catalyzed Ullmann Cross-Coupling/Reductive Cyclization Pathway

Compounds 1-6 and 11 representing key members of the marinoquinoline family of natural products, together with the related marine alkaloid aplidiopsamine A (12), have been synthesized using various combinations of palladium-catalyzed Ullmann cross-coupling and reductive cyclization processes involving a C3-arylated pyrrole as the common intermediate. These natural products have been characterized by single-crystal X-ray analyses and evaluated as inhibitors of acetylcholinesterase (AChE) with congener 2 proving to be the most active.

Development of a Br?nsted acid-promoted arene-ynamide cyclization toward the total syntheses of marinoquinolines A and C and aplidiopsamine A

(Chemical Equation Presented) A Br?nsted acid-promoted arene-ynamide cyclization has been developed to construct the 3H-pyrrolo[2,3-c]quinolines. This reaction consists of the generation of a highly reactive keteniminium intermediate from arene-ynamide activated by a Br?nsted acid and electrophilic aromatic substitution reaction to give arene-fused quinolines in high yields. This methodology enabled facile access to marinoquinolines A and C and aplidiopsamine A.