129572-33-4

Basic information

• Product Name: N-cyclohexyl-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro<1>benzothieno<2,3-c>pyridine-3-carboxamide
• Synonyms: N-cyclohexyl-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro<1>benzothieno<2,3-c>pyridine-3-carboxamide
• CAS NO: 129572-33-4
• Molecular Weight: 414.569
• Mol File: 129572-33-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-cyclohexyl-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro<1>benzothieno<2,3-c>pyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro<1>benzothieno<2,3-c>pyridine-3-carboxamide(129572-33-4)
• EPA Substance Registry System: N-cyclohexyl-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro<1>benzothieno<2,3-c>pyridine-3-carboxamide(129572-33-4)

Safety Data

• Hazardous Substances Data: 129572-33-4(Hazardous Substances Data)

Upstream product

• 116654-74-1 3-thienyl-3>-2-amino-propionsaeureethylester-hydrochlorid 
• 116654-86-5 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro<1>benzothieno<2,3-c>pyridine-3-carboxylic acid ethyl ester 
• 116654-87-6 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro<1>benzothieno<2,3-c>pyridine-3-carboxylic acid 
• 108-91-8 cyclohexylamine 
• 116654-16-1 1,2,3,4-tetrahydro<1>benzothieno<2,3-c>pyridine-3-carboxylic acid ethyl ester 
• 1956-23-6 (R)-α-amino-3-[1]benzothiophene-3-ylpropionic acid 

Downstream Products

• 129592-83-2 N-cyclohexyl-1,2,3,4-tetrahydro<1>benzothieno<2,3-c>pyridine-3-carboxamide hydrochloride 

Relevant articles and documents

Potent Anticonflict Activity and Lessening of Memory Impairment with a Series of Novel Benzothienopyridines and 1,2,3,4-Tetrahydrobenzothienopyridines

Benzothienopyridines (10a-c, 11, 12a-t, and 13a,b) and 1,2,3,4-tetrahydrobenzothienopyridines (3a-c, 7, 8a-c, and 9) were synthesized.The compounds are bioisosteres of β-carbolines and 1,2,3,4-tetrahydro-β-carbolines where the indole nitrogen is replaced by sulfur.Their pharmacological activity was evaluated in a water lick conflict test in rats and a passive avoidance test in mice.In the 1,2,3,4-tetrahydrobenzothienopyridine series, the presence of ethyl ester (3b) or cyclohexyl carboxamide (7) groups at C-3 conferred good anticonflict activity and lessening of memory impairment, while N-acylation of 3b abolished activity.In the benzothienopyridine series, the aminoethyl carboxamide (12a) group at C-3 also conferred activity, but other amides studied were not active.The most potent compounds (3b, 7, and 12a) were also administered orally and had potent anticonflict and antiscopolamine amnesia-reversal activity.These compounds did not bind to the BZP receptor in spite of having structures similar to those of β-carbolines.Compound 7 bound strongly to 5-HT1A receptors and would be expected to be a novel anxiolytic.