1296196-38-7Relevant articles and documents
Rapid determination of enantiomeric excess of α-chiral cyclohexanones using circular dichroism spectroscopy
Leung, Diana,Anslyn, Eric V.
, p. 2298 - 2301 (2011/06/26)
Chemical equations presented. Ketone handedness was discriminated using circular dichroism (CD) spectroscopy by monitoring the metal-to-ligand charge transfer (MLCT) bands of complexes between [CuI((S)-1)(CH 3CN)2]PF6 and derivatized α-chiral cyclohexanones (4). This method was able to quantify the enantiomeric excess of unknown samples using a calibration curve, giving an absolute error of ±7%. The analysis was fast, allowing potential application of this assay in high-throughput screening (HTS).