129740-14-3 Usage
Description
L-AZETIDINE-2-CARBOXYLIC ACID T-BUTYL ESTER, also known as a protected four-membered ring analog of L-Proline, is a significant compound in the field of organic chemistry. It is characterized by its colorless oil appearance and plays a crucial role as an intermediate in the synthesis of polypeptides, which are essential for various biological functions and applications.
Uses
Used in Pharmaceutical Industry:
L-AZETIDINE-2-CARBOXYLIC ACID T-BUTYL ESTER is used as a key intermediate for the synthesis of polypeptides, which are essential in the development of various pharmaceutical products. The compound's unique structure allows for the creation of novel polypeptides with potential therapeutic applications, such as drug delivery systems, enzyme inhibitors, and other bioactive molecules.
Used in Research and Development:
In the field of research and development, L-AZETIDINE-2-CARBOXYLIC ACID T-BUTYL ESTER serves as a valuable tool for scientists to explore new methods and techniques in polypeptide synthesis. Its unique properties enable researchers to investigate the structure-activity relationships of polypeptides and develop new strategies for drug design and optimization.
Used in Chemical Synthesis:
L-AZETIDINE-2-CARBOXYLIC ACID T-BUTYL ESTER is also utilized in various chemical synthesis processes, where its protected four-membered ring structure provides a stable and versatile platform for the development of new compounds with diverse applications. This includes the synthesis of novel polymers, pharmaceuticals, and other specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 129740-14-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,7,4 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 129740-14:
(8*1)+(7*2)+(6*9)+(5*7)+(4*4)+(3*0)+(2*1)+(1*4)=133
133 % 10 = 3
So 129740-14-3 is a valid CAS Registry Number.
129740-14-3Relevant articles and documents
Direct access to L-azetidine-2-carboxylic acid
Bouazaoui, M'barek,Martinez, Jean,Cavelier, Florine
, p. 2729 - 2732 (2009)
A straightforward synthesis of L-azetidine-2-carboxylic acid is described, leading to both orthogonally protected versions or totally deprotected L-Aze. The starting material is a commercially available aspartic acid derivative, whose chirality is conserv
Ring-Strain Effects in Base-Induced Sommelet–Hauser Rearrangement: Application to Successive Stereocontrolled Transformations
Tayama, Eiji,Watanabe, Kazutoshi,Matano, Yoshihiro
, p. 3631 - 3641 (2016/07/29)
The base-induced Sommelet–Hauser (S–H) rearrangement of azetidine-2-carboxylic acid ester-derived ammonium salts into 2-aryl-substituted derivatives was demonstrated. The ring-strain of four-membered N-heterocycles enables efficient generation of the desired ylide intermediate and enhances the rate of the S–H rearrangement. The asymmetric version of the rearrangement was characterized by excellent levels of successive chirality transmissions. The regio- and stereo-controlled nucleophilic ring opening of the rearrangement products produced quaternary α-aryl amino acid esters with excellent enantiopurities.
Total Synthesis of Mugineic Acid. Efficient Use of the Phenyl Group as the Carboxyl Synthon
Matsuura, Fumiyoshi,Hamada, Yasumasa,Shioiri, Takayuki
, p. 8211 - 8222 (2007/10/02)
Stereoselective total synthesis of mugineic acid (1), a unique phytosiderophore from roots of barley, has been achieved from readily available (2S,3S)- and (2R,3R)-2,3-epoxycinnamyl alcohols (5) and (6).The key step is the oxidation of the phenyl group to the carboxylic acid by use of the ruthenium trichloride-sodium metaperiodate system.