129880-21-3

Basic information

• Product Name: Phosphoric acid, diethyl 2-formylphenyl ester
• CAS NO: 129880-21-3
• Molecular Formula: C11H15O5P
• Molecular Weight: 258.211
• Mol File: 129880-21-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Phosphoric acid, diethyl 2-formylphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphoric acid, diethyl 2-formylphenyl ester(129880-21-3)
• EPA Substance Registry System: Phosphoric acid, diethyl 2-formylphenyl ester(129880-21-3)

Safety Data

• Hazardous Substances Data: 129880-21-3(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 762-04-9 phosphonic acid diethyl ester 
• 814-49-3 diethyl chlorophosphate 

Downstream Products

• 807614-51-3 N-(2-diethylphosphonoxy-benzyl)-N-methylamine 
• 129880-28-0 O-diethoxyphosphorysalicylic aldehyde phenylhydrazone 
• 129880-29-1 ethyl-4-(2-O-diethoxyphosphoryloxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 129880-30-4 4-[2-(Diethoxy-phosphoryloxy)-phenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 

Relevant articles and documents

An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines

Herein, a new fluorescent probe, AE-Phos, is reported for detecting the ALP activity with the combined advantages of aggregation-induced emission (AIE) and excited state intramolecular proton transfer (ESIPT). Further detailed fluorescence experiments demonstrated that AE-Phos exhibited excellent selectivity and sensitivity, a large Stokes shift, and a fast response towards ALP. Furthermore, AE-Phos was applied to imaging the ALP activity in different cell lines quantitatively. This journal is

Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues

Alkaline phosphatase (ALP) is a family of enzymes involved in the regulation of important biological processes such as cell differentiation and bone mineralization. Monitoring the activity of ALP in serum can help diagnose a variety of diseases including bone and liver diseases. There has been growing interest in developing new chemical tools for monitoring ALP activity in living systems. Such tools will help further delineate the roles of ALP in biological and pathological processes. Previously reported fluorescent probes has a number of disadvantages that limit their application, such as poor selectivity and short-wavelength excitation. In this work, we report a new two-photon fluorescent probe (TP-Phos) to selectively detect ALP activity. The probe is composed of a two-photon fluorophore, a phosphate recognition moiety, and a self-cleavable adaptor. It offers a number of advantages over previously reported probes, such as fast reaction kinetics, high sensitivity and low cytotoxicity. Experimental results also showed that TP-Phos displayed improved selectivity over DIFMUP, a commonly utilized ALP probe. The selectivity is attributed to the utilization of an ortho-functionalised phenyl phosphate group, which increases the steric hindrance of the probe and the active site of phosphatases. Moreover, the two-photon nature of the probe confers enhanced imaging properties such as increased penetration depth and lower tissue autofluorescence. TP-Phos was successfully used to image the endogenous ALP activity of hippocampus, kidney and liver tissues from rat.

WATER-SOLUBLE SHPS AS NOVEL ALKYLATING AGENTS

The present invention relates to compounds according to the structure (I): Where R is —CH3 or —CH2CH2Cl; R′ is C1-C7 alkyl or —CH2CH2Cl; R2 or R4 is OPOsub