129895-93-8Relevant articles and documents
Nonoxidative coupling methodology for the synthesis of the antitumor bisindole alkaloid vinblastine and a lower-half analogue: Solvent effect on the stereochemistry of the crucial C-15/C-18′ bond
Magnus, Philip,Mendoza, José S.,Stamford, Andrew,Ladlow, Mark,Willis, Paul
, p. 10232 - 10245 (2007/10/02)
The overall strategy for the synthesis of vinblastine (1) is based upon the nonoxidative cleavage of the tertiary amine (+)-18 to generate the intermediate delocalized cation 18a, which in the presence of an electron-rich aromatic nucleophile can be trapp