130191-66-1

Basic information

• Product Name: N-(2,4-difluorophenyl)-2-hydroxy-3-pyridine-carboxamide
• Synonyms: N-(2,4-difluorophenyl)-2-hydroxy-3-pyridine-carboxamide
• CAS NO: 130191-66-1
• Molecular Formula: C₁₂H₈F₂N₂O₂
• Molecular Weight: 250.2009264
• Mol File: 130191-66-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2,4-difluorophenyl)-2-hydroxy-3-pyridine-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-difluorophenyl)-2-hydroxy-3-pyridine-carboxamide(130191-66-1)
• EPA Substance Registry System: N-(2,4-difluorophenyl)-2-hydroxy-3-pyridine-carboxamide(130191-66-1)

Safety Data

• Hazardous Substances Data: 130191-66-1(Hazardous Substances Data)

Upstream product

• 83164-33-4 N-(2,4-difluorophenyl)-2-(3-trifluoromethylphenoxy)-3-pyridinecarboxamide 

Relevant articles and documents

SELECTIVE CLEAVAGE OF THE ETHER AND AMIDE BONDS IN N-(2,4-DIFLUOROPHENYL)-2--3-PYRIDINECARBOXAMIDE (DIFLUFENICAN)

Heated to reflux in water containing 8 gpercent KOH, the herbicide diflufenican -3-pyridinecarboxamide, 1> was selectively transformed into 2--3-pyridinecarboxylic acid (2) plus 2,4-difluoroaniline (5); after 60 hr of heating, 27percent of the initial diflufenican was transformed, yielding 21percent (molepercent relative to initial diflufenican) of compound 2.Heated to reflux in a mixture of acetic acid + concentrate hydrochloric acid, diflufenican was transformed into a mixture of N-(2,4-difluorophenyl)-2-hydroxy-3-pyridinecarboxamide (3) and 2-hydroxy-3-carboxypyridine (4) plus 2,4-difluoroaniline (5) and 3-trifluoromethylphenol (6); after 48 hr of heating, diflufenican was completely transformed, yielding 28percent (molepercent relative to initial diflufenican) of compound 3, and 57percent of compound 4.The base catalyzed hydrolysis thus selectively yielded compound 2; the acid catalyzed one yielded compounds 3 + 4: diflufenican first was transformed into compound 3, which thereafter was transformed into compound 4.