130208-68-3

Basic information

• Product Name: 17β-benzyloxy-3,3-ethylenedioxyestra-5(10),9(11)-diene
• Synonyms: 17β-benzyloxy-3,3-ethylenedioxyestra-5(10),9(11)-diene
• CAS NO: 130208-68-3
• Molecular Weight: 406.565
• Mol File: 130208-68-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 17β-benzyloxy-3,3-ethylenedioxyestra-5(10),9(11)-diene(CAS DataBase Reference)
• NIST Chemistry Reference: 17β-benzyloxy-3,3-ethylenedioxyestra-5(10),9(11)-diene(130208-68-3)
• EPA Substance Registry System: 17β-benzyloxy-3,3-ethylenedioxyestra-5(10),9(11)-diene(130208-68-3)

Safety Data

• Hazardous Substances Data: 130208-68-3(Hazardous Substances Data)

Upstream product

• 6218-29-7 17β-hydroxyestra-4,9-dien-3-one 
• 53303-91-6 (8S,13S,14S,17S)-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-ol 
• 100-44-7 benzyl chloride 

Downstream Products

• 130320-62-6 17β-benzyloxy-3,3-ethylenedioxy-5α,10α-oxidoestre-9(11)-ene 
• 130208-70-7 17β-benzyloxy-3,3-ethylenedioxy-5β,10β-oxidoestre-9(11)-ene 

Relevant articles and documents

EPOXIDATION OF ESTRA-5(10),9(11)-DIENE DERIVATIVES; A CONVENIENT SYNTHESIS OF 11Β-VINYLESTRONE ACETATE

The title compound has been prepared from 17β-hydroxyestra-4,9(10)-dien-3-one, 1, in a sixstep synthesis requiring only one purification and providing a 58percent overall yield.The key steps of the synthesis are the regio- and stereo-selective epoxidation of 3,3:17,17-bis(ethylenedioxy)-estra-5(10),9(11)-diene, 2e, to yield the corresponding 5α,10α-epoxide derivative using hydrogen peroxide and hexafluoroacetone, followed by the copper(I)-catalyzed conjugate opening of the vinyl epoxide by vinylmagnesium bromide.A variety of extra-5(10),9(11)-diene derivatives differing for substitution at C-17 were also regio- and stereo-selectively epoxidized.