130209-77-7 Usage
Synthetic chemical compound
Derived from the natural prostaglandin F2 alpha.
Common use
Research and pharmaceutical applications.
Agonist
Potent and selective agonist of the prostaglandin F receptor.
Therapeutic potential
Studied for conditions such as glaucoma, asthma, and labor induction.
1-isopropyl ester structure
Provides enhanced stability and improved pharmacokinetic properties.
Valuable tool
For studying the biological functions and signaling pathways of prostaglandin receptors.
Phenyl substitution
At the 17th carbon position, which may confer specific binding interactions and modulate the compound's pharmacological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 130209-77-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,2,0 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 130209-77:
(8*1)+(7*3)+(6*0)+(5*2)+(4*0)+(3*9)+(2*7)+(1*7)=87
87 % 10 = 7
So 130209-77-7 is a valid CAS Registry Number.
InChI:InChI=1/C26H36O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,16-17,19,22-25,28-29H,4,9,12-15,18H2,1-2H3/b8-3-,17-16+/t22-,23-,24+,25-/m1/s1
130209-77-7Relevant articles and documents
Regio- and stereoselective reactions of 17-phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester
Liljebris, Charlotta,Nilsson, Bj?rn M.,Resul, Bahram,Hacksell, Uli
, p. 4028 - 4034 (2007/10/03)
Novel prostaglandin F2α derivatives, functionalized at C13 and C14, have been prepared. 17-Phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester [(15S)-1] and its epimer [(15A)-1] were stereoselectively epoxidized, using Sharpless conditions, to produce each of the four diastereomeric epoxides (15S)-2, (15S)-3, (15R)-2, and (15R)-3. Treatment of the four epoxides with LiOH stereospecifically-produced the pentahydroxy substituted analogues 12 and 13. Alternatively, epoxides 2 and 3 were allowed to react with thiophenolate ion. The attack of the sulfur nucleophile on the epoxide occurred at either C13 or C14 depending on the stereochemistry of the epoxide and of C15.