130220-57-4

Basic information

• Product Name: 2-(4-methoxyphenoxymethyl)-3-pyridinecarboxylic acid
• Synonyms: 2-(4-methoxyphenoxymethyl)-3-pyridinecarboxylic acid
• CAS NO: 130220-57-4
• Molecular Weight: 259.262
• Mol File: 130220-57-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenoxymethyl)-3-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenoxymethyl)-3-pyridinecarboxylic acid(130220-57-4)
• EPA Substance Registry System: 2-(4-methoxyphenoxymethyl)-3-pyridinecarboxylic acid(130220-57-4)

Safety Data

• Hazardous Substances Data: 130220-57-4(Hazardous Substances Data)

Upstream product

• 5657-51-2 7H-furo[3,4-b]pyridin-5-one 
• 150-76-5 4-methoxy-phenol 
• 108-95-2 phenol 
• 81113-14-6 2-hydroxymethyl-3-pyridinecarboxylic acid 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 

Downstream Products

• 130220-83-6 N-Cyclohexyl-N'-(7-methoxy-5,11-dihydro-10-oxa-1-aza-dibenzo[a,d]cyclohepten-5-yl)-propane-1,3-diamine 
• 115749-98-9 N,N-Diethyl-N'-(7-methoxy-5,11-dihydro-10-oxa-1-aza-dibenzo[a,d]cyclohepten-5-yl)-ethane-1,2-diamine 
• 115749-98-9 N,N-Diethyl-N'-(7-methoxy-5,11-dihydro-10-oxa-1-aza-dibenzo[a,d]cyclohepten-5-yl)-ethane-1,2-diamine 
• 115749-98-9 5-<<2-(diethylamino)ethyl>amino>-7-methoxy-5,11-dihydro<1>benzoxepino<3,4-b>pyridine 

Relevant articles and documents

A facile synthesis of substituted 5,11-dihydro[1]benzoxepino[3,4-b]pyridines

5-Amino-5,11-dihydro[1]benzoxepino[3,4-b]pyridines (1) show anti-ulcer and antiarrhythmic activity. An efficient method for the preparation of a key intermediate, furo[3,4-b]pyridin-5(7H)-one (4), and the facile synthesis of 1 were described. The reduction of quinolinic anhydride (5) with sodium borohydride in the presence of acetic acid regioselectively gave the lactone 4. Lactone 4 was then reacted with substituted phenols under basic conditions and the resultant products, 2-(phenoxymethyl)-3-pyridinecarboxylic acids (3), underwent Friedel-Crafts cyclizations to produce the 5,11-dihydro[1]benzoxepino[3,4-b]pyridin-5-ones (2). Compounds 2 were then converted to imines with amines and successively reduced with zinc in acetic acid to the desired compounds 1.