130250-62-3

Basic information

• Product Name: 2,N-DIMETHOXY-N-METHYLBENZAMIDE
• Synonyms: 2,N-DIMETHOXY-N-METHYLBENZAMIDE;N-2-DiMethoxy-N-MethylbenzaMide;2-Methoxy-N-Methoxy-N-MethylbenzaMide
• CAS NO: 130250-62-3
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.22
• Mol File: 130250-62-3.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,N-DIMETHOXY-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,N-DIMETHOXY-N-METHYLBENZAMIDE(130250-62-3)
• EPA Substance Registry System: 2,N-DIMETHOXY-N-METHYLBENZAMIDE(130250-62-3)

Safety Data

• Hazardous Substances Data: 130250-62-3(Hazardous Substances Data)

Usage

General Description

2,N-DIMETHOXY-N-METHYLBENZAMIDE is a chemical compound that is commonly used as a building block in organic synthesis and pharmaceutical research. It is a substituted benzamide derivative with two methoxy groups on the phenyl ring and a methyl group attached to the amide nitrogen. 2,N-DIMETHOXY-N-METHYLBENZAMIDE has the potential to be used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It has been studied for its potential biological activities and has shown promise as a potential drug candidate in some research studies. Additionally, it is used in various chemical reactions as a reagent and has also been investigated for its potential use in material science and polymer chemistry.

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 579-75-9 2-Methoxybenzoic acid 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 578-57-4 2-bromoanisole 
• 201230-82-2 carbon monoxide 
• 612-16-8 (2-methoxyphenyl)methanol 
• 30289-28-2 N-methoxy-N-methylcarbamoyl chloride 

Downstream Products

• 749888-05-9 2-ethoxy-1-(2-methoxy-phenyl)-propenone 
• 5449-69-4 2,4'-dimethoxybenzophenone 
• 256475-07-7 (2-methoxyphenyl)[4-(trifluoromethyl)phenyl]methanone 
• 749888-20-8 3-ethoxy-2-(2-methoxy-phenyl)-1-trimethylsilanyl-but-3-en-2-ol 
• 152122-02-6 4-(2-Methoxyphenyl)-2-(4-methylthiophenyl)-5-(pyridin-4-yl)-1H-imidazole 
• 1071454-80-2 (5-bromo2-fluoro-pyridin-3-yl)-(2-methoxy-phenyl)-methanone 
• 1158955-24-8 C₁₃H₉F₂NO₂ 
• 131117-96-9 3-(2-methoxybenzoyl)benzonitrile 
• 1394949-23-5 C₁₆H₂₀O₅ 

Relevant articles and documents

Biocatalytic Strategy for the Highly Stereoselective Synthesis of CHF2-Containing Trisubstituted Cyclopropanes

The difluoromethyl (CHF2) group has attracted significant attention in drug discovery and development efforts, owing to its ability to serve as fluorinated bioisostere of methyl, hydroxyl, and thiol groups. Herein, we report an efficient biocat

An efficient and versatile synthesis of isoflavones from 2-methoxybenzoic acids

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A small-molecule cell-based screen led to the identification of biphenylimidazoazines with highly potent and broad-spectrum anti-apicomplexan activity

An in vitro screening of the anti-apicomplexan activity of 51 compounds, stemming from our chemical library and from chemical synthesis, was performed. As a study model, we used Toxoplasma gondii (T. gondii), expressing β-galactosidase for the colorimetric assessment of drug activity on parasites cultivated in vitro. This approach allowed the validation of a new series of molecules with a biphenylimidazoazine scaffold as inhibitors of T. gondii growth in vitro. Hence, 8 molecules significantly inhibited intracellular replication of T. gondii in vitro, with EC50 50 in the submicromolar to nanomolar range, for each parasite. These data, including the broad anti-parasite spectrum of these inhibitors, define a new generation of potential anti-parasite compounds of wide interest, including for veterinary application. Studies realized on E. tenella suggest that these molecules act during the intracellular development steps of the parasite. Further experiments should be done to identify the molecular target(s) of these compounds.