130305-58-7Relevant articles and documents
Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists
Conway, Richard J.,Valant, Celine,Christopoulos, Arthur,Robertson, Alan D.,Capuano, Ben,Crosby, Ian T.
supporting information; experimental part, p. 2560 - 2564 (2012/05/05)
A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein.
A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans.
Kim, In Jong,Dersch, Christina M,Rothman, Richard B,Jacobson, Arthur E,Rice, Kenner C
, p. 4543 - 4550 (2007/10/03)
The opioid receptor binding affinities of N-methyl- and N-phenethyl-5-phenylmorphans with a meta-hydroxy substituent [3-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (1a), and 3-(2-phenethyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (1b)] were compared with the
Structure-activity relationships for the binding of arylpiperazines and arylbiguanides at 5-HT3 serotonin receptors
Dukat, Malgorzata,Abdel-Rahman, Ashraf A.,Ismaiel, Abd M.,Ingher, Stacy,Teitler, Milt,Gyermek, Laszlo,Glennon, Richard A.
, p. 4017 - 4026 (2007/10/03)
Arylpiperazines are nonselective agents that bind at 5-HT3 serotonin receptors with moderate to high affinity, whereas 1-phenylbiguanide is a low- affinity but more selective 5-HT3 agonist. In an attempt to enhance the affinity of th
