130312-20-8

Basic information

• Product Name: 1-cyano-1-methyl-ethylphenylcarbonate
• Synonyms: 1-cyano-1-methyl-ethylphenylcarbonate
• CAS NO: 130312-20-8
• Molecular Weight: 205.213
• Mol File: 130312-20-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-cyano-1-methyl-ethylphenylcarbonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyano-1-methyl-ethylphenylcarbonate(130312-20-8)
• EPA Substance Registry System: 1-cyano-1-methyl-ethylphenylcarbonate(130312-20-8)

Safety Data

• Hazardous Substances Data: 130312-20-8(Hazardous Substances Data)

Upstream product

• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 1885-14-9 phenyl chloroformate 

Downstream Products

• 1272973-17-7 2-cyanopropan-2-yl 4-(5-(4-(methylsulfonyl)benzyloxy)pyrimidin-2-yl)piperazine-1-carboxylate 
• 130310-35-9 6-(2-chlorophenyl)-3-(1-cyano-1-methylethoxycarbonyl)-11-methyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4:5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine 

Relevant articles and documents

Structure-activity studies on triazolothienodiazepine derivatives as platelet-activating factor antagonists

A series of triazolodiazepines was synthesized and evaluated for anti-platelet activating factor (PAF) activities. Structure-activity relationship (SAR) studies on this series revealed that the introduction of a methyl group into the 8-position of the thienodiazepine nucleus can lead to a lengthening of the duration of action. Introduction of a methyl group produced an asymmetric center and the enantiomers so formed were separated with an optical resolving column. In the in vitro assay system, the (+)-isomers displayed 50-200 times more potent anti-PAF activity than the (-)-isomers. After comparison of toxicology and pharmacokinetics, (+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5-tet rahydro-8H-pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]dia zepine (35(+)-isomer, E6123) was selected from among the compounds synthesized as a candidate for clinical study.