1304668-78-7

Basic information

• Product Name: (R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate
• Synonyms: (R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate
• CAS NO: 1304668-78-7
• Molecular Weight: 443.338
• Mol File: 1304668-78-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate(1304668-78-7)
• EPA Substance Registry System: (R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate(1304668-78-7)

Safety Data

• Hazardous Substances Data: 1304668-78-7(Hazardous Substances Data)

Upstream product

• 99-90-1 para-bromoacetophenone 
• 80909-78-0 p-bromo-α-methylstyrene oxide 
• 870-50-8 di-tert-butyl-diazodicarboxylate 
• 40460-91-1 2-(4-bromophenyl)propanal 

Relevant articles and documents

β-tert-Butyl aspartate as an organocatalyst for the asymmetric α-amination of α,α-disubstituted aldehydes

The enantioselective α-amination reaction of α,α- disubstituted aldehydes can lead to a variety of enantioenriched amino aldehydes, amino alcohols, and amino acids. After screening a variety of amino acids and their derivatives, we identified a cheap, simple, commercially available aspartic acid derivative that can catalyze efficiently the reaction between α,α-disubstituted aldehydes and dialkyl azodicarboxylates. The reaction proceeds smoothly leading to the corresponding α-aminated adducts in moderate to quantitative yields and moderate to high enantioselectivities (up to 96% ee). Finally, the conversion of these adducts to α,α-disubstituted quaternary amino acids is also described.